Skip to Content
Merck
CN
All Photos(4)

Documents

H6034

Sigma-Aldrich

L-Histidine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, USP testing specifications

Sign Into View Organizational & Contract Pricing
All Photos(4)
Synonym(s):
(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
71-00-1
Molecular Weight:
155.15
Beilstein:
84088
EC Number:
200-745-3
MDL number:
MFCD00064315
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895728
NACRES:
NA.26

biological source

non-animal source

Quality Level

300

Agency

meets EP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

optical activity

[α]20/D 12.0 to 12.8 °, c = 11 in 6 M HCl
[α]25/D 12.6 to 14.0 °, c = 11 in 6 M HCl

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

282 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

cation traces

As: ≤1 ppm
Fe: ≤10 ppm
NH4+: <0.02%

application(s)

peptide synthesis
pharmaceutical (small molecule)

functional group

(Imidazole)
amine
carboxylic acid

storage temp.

room temp

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759) , CA2(760)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

L-Histidine is a proteinogenic amino acid and an essential amino acid required for histamine production. This positively charged amino acid is vital for growth, tissue repair, myelin sheath maintenance, and histamine synthesis. Histamine plays critical roles in immunity, gastric secretion, and more. L-Histidine is essential for blood cell production and tissue protection against radiation and heavy metals. L-Histidine plays a role as a metabolite and also acts as a cofactor in enzyme protection during protein synthesis. It is an L-enantiomer of histidine and is necessary for histamine synthesis and human development. L-Histidine finds applications in cell culture, metabolomics and biochemical research.

Application

L-histidine has been used as a component in agar plates containing 5-fluorocytosine (5-FC) for the selection of yeast transformants. It has also been used as a component of adult mouse keratinocyte growth medium.

Biochem/physiol Actions

L-Histidine is an essential amino acid that binds to metal ions and may aid in the transport of copper. Histidine is widely present at the active sites of enzymes. It also has a role in binding of heme groups, macromolecules and phosphate groups in the binding sites of proteins.
Precursor of histamine by action of histidine decarboxylase.

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Application

Product No.
Description
Pricing

comparable product

Product No.
Description
Pricing

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Eric R. Braverman
The Healing Nutrients Within: Facts, Findings, and New Research on Amino Acids (2003)
A method for high-throughput production of sequence-verified DNA libraries and strain collections

Roger L. Lundblad
Justin D
Molecular Systems Biology (2017)
Catherine Collin
Advances in Neurochemistry (2005)
Serial Cultivation of Primary Adult Murine Keratinocytes
Richard P. Redvers and Pritinder Kaur
Methods in Molecular Biology (2005)
Shweta Singh et al.
Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
View All Related Papers

Chromatograms

application for HPLC

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service