Skip to Content
Merck
CN
All Photos(4)

Documents

H5659

Sigma-Aldrich

L-Histidine monohydrochloride monohydrate

98.5-101.0%, suitable for cell culture, BioXtra, non-animal source

Sign Into View Organizational & Contract Pricing
All Photos(4)
Synonym(s):
L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride
Empirical Formula (Hill Notation):
C6H9N3O2 · HCl · H2O
CAS Number:
5934-29-2
Molecular Weight:
209.63
Beilstein:
4168261
MDL number:
MFCD00151027
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895703
NACRES:
NA.26

biological source

non-animal source

Quality Level

300

Agency

meets EP testing specifications

product line

BioXtra

Assay

98.5-101.0%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

254 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

L-Histidine monohydrochloride monohydrate has been used in bee cell culture medium.
L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yoshihiro Kaneko et al.
Journal of bioscience and bioengineering, 109(3), 274-280 (2010-02-18)
Pharmaceutical manufacturing plants can be operated continuously for several months. It is therefore important to use cells with long-term stability for the production of active ingredients. We investigated the reliability and long-term stability of an antibody-producing cell line. A recombinant
D J Williams et al.
IEE proceedings. Nanobiotechnology, 152(6), 207-210 (2006-01-31)
Tissue engineering and regenerative medicine are interdisciplinary fields that apply principles of engineering and life sciences to develop biological substitutes, typically composed of biological and synthetic components, that restore, maintain or improve tissue function. Many tissue engineering technologies are still
Jean-Christophe Drugmand et al.
Biotechnology advances, 30(5), 1140-1157 (2011-10-11)
Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of baculovirus expression vector systems (BEVS), constitutes a powerful platform, IC-BEVS, for the abundant and
Medium for development of bee cell cultures (Apis mellifera: Hymenoptera: Apidae).
Hunter WB
In Vitro Cellular & Developmental Biology. Animal, 46(2), 83-86 (2010)
Carlota Diaz Sanchez-Bustamante et al.
Biotechnology and bioengineering, 93(1), 169-180 (2005-10-29)
A precise understanding of processes managing heterologous protein production in vitro and in vivo is essential for the manufacture of sophisticated biopharmaceuticals as well as for future gene therapy and tissue engineering initiatives. Capitalizing on the gravity-enforced self-assembly of monodispersed
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service