Key Documents

View All Documentation

H5653

8-Hydroxy-2′-deoxyguanosine

Name: 8-Hydroxy-2&#8242;-deoxyguanosine
Brand: SIGMA

≥98% (TLC), DNA damage biomaker

Synonym(s):

8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃N₅O₅

CAS Number:

88847-89-6

Molecular Weight:

283.24

UNSPSC Code:

12352200

PubChem Substance ID:

24895702

NACRES:

NA.77

MDL number:

MFCD00210311

Assay:

≥98% (TLC)

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

8-Hydroxy-2′-deoxyguanosine, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

storage temp.

2-8°C

SMILES string

O=C1C(NC(N2C3CC(O)C(CO)O3)=O)=C2NC(N)=N1

InChI

1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)

InChI key

HCAJQHYUCKICQH-UHFFFAOYSA-N

Description

Application

8-Hydroxy-2′-deoxyguanosine has been used:

as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential antioxidant activity of green coffee bean extract (GCBE) in vivo
as a standard for LC/MS/MS analysis

Biochem/physiol Actions

The levels of 8-hydroxy-2′-deoxyguanosine helps in evaluating oxidative stress and DNA damage in individuals suffering from laryngeal cancer. Hence it serves as a major biomarker of DNA damage, induced by reactive oxygen species (ROS).

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000424169

0000395821

0000378364

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents.

Arif Malik et al.

Drug design, development and therapy, 12, 1431-1443 (2018-06-07)

The present study investigates the hepato- and DNA-protective effects of standardized extracts of Cleome brachycarpa (cabralealactone), Solanum incanum (solasodin), and Salvadora oleioides (salvadorin) in rats. Hepatotoxicity was induced with intraperitoneal injection of carbon tetrachloride (CCl4) (1 mL/kg b.wt.) once a

Ginger extract protects rat's kidneys against oxidative damage after chronic ethanol administration.

Aireza Shirpoor et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 698-704 (2016-10-07)

Chronic alcohol ingestion is associated with pronounced detrimental effects on the renal system. In the current study, the protective effect of ginger extract on ethanol-induced damage was evaluated through determining 8-OHdG, cystatin C, glomerular filtration rate, and pathological changes such

Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence

Huang M C, et al.

The American Journal of Drug and Alcohol Abuse, 44(3), 395-402 (2018)

View All Related Papers

Global Trade Item Number

SKU	GTIN
H5653-1MG	04061833799635
H5653-5MG	04061833799642