H4539
Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-HD11, Anti-HDAC11
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~39 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
western blot (chemiluminescent): 0.5-1 μg/mL using extracts of mouse brain
western blot (chemiluminescent): 4-6 μg/mL using nuclear extracts of HeLa cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HDAC11(79885)
mouse ... Hdac11(232232)
rat ... Hdac11(297453)
Related Categories
General description
Anti-Histone Deacetylase 11 (HDAC11) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH, as immunogen. Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6. This gene is mapped to human chromosome 3p25.
Immunogen
synthetic peptide corresponding to amino acids 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by three amino acids in both rat and mouse HDAC11.
Application
Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting analysis.
Biochem/physiol Actions
Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Histone Deacetylase 11 (HDAC11) modulates immune activation and tumorigenesis. It negatively controls the synthesis of interleukin-10 (IL-10) in antigen-presenting cells (APCs). It also modulates type I interferon (IFN) signalling.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
Villagra A, et al.
Nature Immunology, 10(1), 92-100 (2008)
Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family
Gao L, et al.
The Journal of Biological Chemistry, 277(28), 25748-25755 (2002)
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
Cao J, et al.
Proceedings of the National Academy of Sciences of the USA, 116(12), 5487-5487 (2019)
Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells
Xu X, et al.
Testing, 6(2), e17138-e17138 (2011)
Eva Sahakian et al.
Journal of leukocyte biology, 102(2), 475-486 (2017-05-28)
Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes in normal and malignant processes. HDAC11, the newest member of the HDAC family of enzymes, functions as a negative regulator of IL-10 expression in
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