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Merck
CN

H3131

2-Hydroxyestradiol

≥95% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-2,3-17β-triol, Estra-1,3,5(10)-triene-2,3,17-triol, NSC 61711

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About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
362-05-0
Molecular Weight:
288.38
NACRES:
NA.77
PubChem Substance ID:
24895552
UNSPSC Code:
12352200
MDL number:
MFCD00010490

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InChI

1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)c(O)cc34)[C@@H]1CC[C@@H]2O

InChI key

DILDHNKDVHLEQB-XSSYPUMDSA-N

biological source

synthetic (organic)

sterility

non-sterile

assay

≥95% (HPLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, faintly yellow to yellow

shipped in

ambient

storage temp.

−20°C

Gene Information

rat ... Ar(24208)

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

pcodes

P281

Hazard Classifications

Carc. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH3649
MKCF9889
MKCC5942
MKBZ4229V
MKBX3313V

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Tara M D'Eon et al.
Obesity (Silver Spring, Md.), 16(6), 1284-1288 (2008-04-19)
Systemic loss of estradiol (E2) during menopause is associated with increased adiposity which can be prevented with E2 replacement. Rodent studies suggest that E2, or lack of, is a key mediator in menopause-related metabolic changes. We have previously demonstrated that
Xiaoying Qiao et al.
Gender medicine, 5 Suppl A, S46-S64 (2008-05-28)
Sex hormones play a significant role in human physiology. Estrogen may have protective effects in the cardiovascular system, as evidenced by the decreased incidence of cardiovascular disease (CVD) in premenopausal compared with postmenopausal women. This review highlights the acute and
K Takanashi et al.
Clinical chemistry, 46(3), 373-378 (2000-03-07)
Preeclampsia is associated with a quantitative imbalance between lipid peroxide and an antioxidant coproduced in the placenta. To investigate our hypothesis that 2-hydroxyestradiol 17-sulfate (2-OH-ES) is the placental antioxidant during pregnancy, we developed an assay for 2-OH-ES in urine and
Water-soluble products of the estrogens. Bile metabolites of 2-hydroxyestradiol-17beta in man.
J S Elce et al.
The Journal of clinical endocrinology and metabolism, 36(5), 1027-1030 (1973-05-01)
R K Babbs et al.
Physiology & behavior, 103(5), 508-512 (2011-04-19)
One conundrum of binge eating is that women are more likely to suffer from binge-related disorders, even though estradiol decreases food intake. 2-hydroxyestradiol (2OHE2), an estrogen metabolite, may account for the contradiction, due to possible interference with DA signaling. We
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