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Safety Information

H3131

Sigma-Aldrich

2-Hydroxyestradiol

≥95% (HPLC)

Synonym(s):

1,3,5(10)-Estratriene-2,3-17β-triol, Estra-1,3,5(10)-triene-2,3,17-triol, NSC 61711

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About This Item

Empirical Formula (Hill Notation):
C18H24O3
CAS Number:
362-05-0
Molecular Weight:
288.38
MDL number:
MFCD00010490
UNSPSC Code:
12352200
PubChem Substance ID:
24895552
NACRES:
NA.77

biological source

synthetic (organic)

sterility

non-sterile

Assay

≥95% (HPLC)

form

powder

solubility

ethanol: 20 mg/mL, clear, faintly yellow to yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CCc4cc(O)c(O)cc34)[C@@H]1CC[C@@H]2O

InChI

1S/C18H24O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,17,19-21H,2-7H2,1H3/t11-,12+,14-,17-,18-/m0/s1

InChI key

DILDHNKDVHLEQB-XSSYPUMDSA-N

Gene Information

rat ... Ar(24208)

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Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCH3649
MKCF9889
MKCC5942
MKBZ4229V
MKBX3313V

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Weidong Geng et al.
Journal of cellular physiology, 220(2), 332-340 (2009-04-11)
High [HCO(3)(-)] inhibits and low [HCO(3)(-)] stimulates bone resorption, which mediates part of the effect of chronic acidosis or acid feeding on bone. Soluble adenylyl cyclase (sAC) is a bicarbonate sensor that can potentially mediate the effect of bicarbonate on
R K Babbs et al.
Physiology & behavior, 103(5), 508-512 (2011-04-19)
One conundrum of binge eating is that women are more likely to suffer from binge-related disorders, even though estradiol decreases food intake. 2-hydroxyestradiol (2OHE2), an estrogen metabolite, may account for the contradiction, due to possible interference with DA signaling. We
Water-soluble products of the estrogens. Bile metabolites of 2-hydroxyestradiol-17beta in man.
J S Elce et al.
The Journal of clinical endocrinology and metabolism, 36(5), 1027-1030 (1973-05-01)
G Basini et al.
The Journal of endocrinology, 199(1), 127-135 (2008-07-30)
The rapid, controlled, and cyclical nature of angiogenesis in the ovarian follicle suggests the potential for sex steroids to influence neovascularization. Angiogenesis is regulated by a local balance between the levels of endogenous stimulators and inhibitors. Multiple lines of evidence
Christine Schlicker et al.
Journal of medicinal chemistry, 51(15), 4456-4464 (2008-07-18)
In mammals, the second messenger cAMP is synthesized by a family of transmembrane isoforms (tmACs) and one known cytoplasmic enzyme, "soluble" adenylyl cyclase (sAC). Understanding the individual contributions of these families to cAMP signaling requires tools which can distinguish them.
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