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Safety Information

H2164

Sigma-Aldrich

Anti-HP1α antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Antigen p25, Anti-Chromobox Protein Homolog 5, Anti-Heterochromatin Protein 1 Homolog α

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About This Item

MDL number:
MFCD08705463
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~22 kDa

species reactivity

human, mouse

technique(s)

immunoprecipitation (IP): 5-10 μg using RIPA lysate of human HeLa cells
indirect immunofluorescence: 5-10 μg/mL using mouse NIH3T3 cells
western blot (chemiluminescent): 1-2 μg/mL using whole extract of human HeLa cells

UniProt accession no.

P45973

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CBX5(23468)
mouse ... Cbx5(12419)

Immunogen

synthetic peptide corresponding to amino acid residues 177-191 of human HP1a with N-terminal added cysteine, conjugated to KLH. The corresponding sequence in mouse differs by one amino acid.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
055K4810

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Christèle Maison et al.
Nature communications, 7, 12224-12224 (2016-07-19)
The trimethylation of histone H3 on lysine 9 (H3K9me3) - a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) - has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in
Shinichi Machida et al.
Molecular cell, 69(3), 385-397 (2018-01-18)
Heterochromatin plays important roles in transcriptional silencing and genome maintenance by the formation of condensed chromatin structures, which determine the epigenetic status of eukaryotic cells. The trimethylation of histone H3 lysine 9 (H3K9me3), a target of heterochromatin protein 1 (HP1), is
Alba Millanes-Romero et al.
Molecular cell, 52(5), 746-757 (2013-11-19)
Although heterochromatin is enriched with repressive traits, it is also actively transcribed, giving rise to large amounts of noncoding RNAs. Although these RNAs are responsible for the formation and maintenance of heterochromatin, little is known about how their transcription is
Julio Aguado et al.
Nature communications, 10(1), 4990-4990 (2019-11-20)
Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction
Joseph Dopie et al.
The Journal of cell biology, 219(9) (2020-07-02)
We present a simple ratio method to infer protein composition within cellular structures using proximity labeling approaches but compensating for the diffusion of free radicals. We used tyramide signal amplification (TSA) and label-free mass spectrometry (MS) to compare proteins in
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