H156
(+)-3-Hydroxymorphinan hydrobromide
Synonym(s):
(+)-9α,13α,14α-Morphinan-3-ol
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About This Item
Empirical Formula (Hill Notation):
C16H21NO · HBr
CAS Number:
Molecular Weight:
324.26
PubChem Substance ID:
UNSPSC Code:
12352204
InChI
1S/C16H21NO.BrH/c18-12-5-4-11-9-15-13-3-1-2-6-16(13,7-8-17-15)14(11)10-12;/h4-5,10,13,15,17-18H,1-3,6-9H2;1H/t13-,15+,16+;/m1./s1
InChI key
LJAQABDSIONCIU-KHUAAREISA-N
SMILES string
Br.Oc1ccc2C[C@@H]3NCC[C@]4(CCCC[C@H]34)c2c1
Quality Level
assay
≥98% (HPLC)
form
powder
drug control
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
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High-performance liquid chromatographic determination of dextrorphan and 3-hydroxymorphinan in human plasma based on a selective pre-column sample clean-up.
H Mascher
Journal of chromatography, 420(1), 217-222 (1987-09-04)
Jong Yup Kim et al.
Chemical & pharmaceutical bulletin, 56(7), 985-987 (2008-07-02)
Dimemorfan (DF) has been known to possess neuroprotective properties. While this promising compound deserves further biological evaluation, synthetic methods have not improved since Murakami group unveiled the synthetic efforts in 1972. Herein a succinct synthesis toward DF from commercially available
Z R Chen et al.
Therapeutic drug monitoring, 12(1), 97-104 (1990-01-01)
A simple, sensitive, and reproducible high-performance liquid chromatrography assay is described for the simultaneous determination of dextromethophan, dextrorphan, 3-hydroxymorphinan, and 3-methoxymorphinan in plasma and urine. A conventional solvent-solvent extraction procedure was used for the isolation of the analytes from plasma
K C Carlsson et al.
Acta anaesthesiologica Scandinavica, 48(3), 328-336 (2004-02-26)
Dextromethorphan, a clinically available N-methyl-D-aspartic acid (NMDA) receptor antagonist, has an analgesic effect in patients with diabetic neuropathy. The aim of this study was to evaluate the analgesic and adverse effects of a single high dose of dextromethorphan on spontaneous
Eun-Joo Shin et al.
Journal of pharmacological sciences, 106(1), 22-27 (2008-01-17)
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects. Accumulating evidence suggests that metabolism to
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