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H1392

Sigma-Aldrich

Harmaline hydrochloride dihydrate

≥95%

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Synonym(s):
1-Methyl-7-methoxy-3,4-dihydro-β-carboline hydrochloride
Empirical Formula (Hill Notation):
C13H14N2O · HCl · 2H2O
CAS Number:
6027-98-1
Molecular Weight:
286.75
Beilstein:
6493114
MDL number:
MFCD00150052
UNSPSC Code:
12352200
PubChem Substance ID:
24895457
NACRES:
NA.25

Assay

≥95%

drug control

stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

forensics and toxicology

storage temp.

−20°C

SMILES string

Cl[H].[H]O[H].[H]O[H].COc1ccc2c3CCN=C(C)c3[nH]c2c1

InChI

1S/C13H14N2O.ClH.2H2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;;;/h3-4,7,15H,5-6H2,1-2H3;1H;2*1H2

InChI key

LCEKUHFBUFUSSY-UHFFFAOYSA-N

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Biochem/physiol Actions

CNS stimulant; may act through NMDA receptors

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H371

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 2

Target Organs

Central nervous system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Barbara Kosmowska et al.
Neurochemical research, 45(7), 1518-1525 (2020-03-17)
Essential tremor is one of the most common neurological disorders, however, it is not sufficiently controlled with currently available pharmacotherapy. Our recent study has shown that pramipexole, a drug efficient in inhibiting parkinsonian tremor, reduced the harmaline-induced tremor in rats
Hassan Abbassian et al.
British journal of pharmacology, 173(22), 3196-3207 (2016-10-21)
Essential tremor (ET) is a neurological disorder with unknown aetiology. Its symptoms include cerebellar motor disturbances, cognitive and personality changes, hearing and olfactory deficits. Hyperactivity of excitotoxic cerebellar climbing fibres may underlie essential tremor and has been induced in rodents
Fatemeh Mohammadi et al.
Neuroscience letters, 704, 153-158 (2019-04-12)
There are conflicting reports concerning the association of motor disabilities with increased risk of mental disorders. This investigation will provide a good understanding about defining the possible association between tremor and risk of anxiety and cognitive alterations. Beside, a secondary
Sarah Eller et al.
Forensic science international, 312, 110298-110298 (2020-05-11)
Ayahuasca is a beverage composed by a mixture of herbs which contain the compound N,N-dimethyltriptamine (DMT) and the β-carbolines. Although its use is legalized in Brazil only for religious and spiritual ceremonies, there is a growing black market specialized in
Krystyna Ossowska et al.
Pharmacological reports : PR, 67(3), 435-441 (2015-05-03)
Harmaline-induced tremor is a well-known model of essential tremor in humans. The aim of the present study was to examine the influence of apomorphine, a non-selective dopamine receptor agonist, on the tremor induced by harmaline in rats. Propranolol (a first-line

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