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H1291

Sigma-Aldrich

Anti-HOXA1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-HXA1, Anti-Homeobox A1, Anti-Hox-1.6, Anti-Hox-1F

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~43 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:1,000 using lysate of HEK-293T cells over expressing human HOXA1

UniProt accession no.

P49639

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HOXA1(3198)

General description

The HOXA1 gene is a member of the homeobox (HOX) gene family and is mapped on the human chromosome at 7p15.2.

Specificity

Anti-HOXA1 specifically recognizes human HOXA1 (also known as Hox-1F, HXA1).

Application

Anti-HOXA1 antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Homeobox A1 (HOXA1) protein is involved in hindbrain segmentation and patterning. Misregulation of the HOXA1 gene is associated with breast cancer. HOXA1 gene disruption results in abnormal ossification of the skull, hindbrain, and inner ear deficiencies, and neonatal death.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Lot/Batch Number
059K4771

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Liliana A Muñoz-Pedroza et al.
Acta otorrinolaringologica espanola, 64(5), 359-362 (2013-07-31)
Facio-Auriculo-Vertebral (FAV) spectrum, also known as Goldenhar syndrome or first and second branchial arch syndrome, is a complex of mainly craniofacial and vertebral anomalies. Microtia is a principal malformation in this complex; it can be unilateral or bilateral. We performed
Barbara Lambert et al.
BMC developmental biology, 12, 29-29 (2012-10-24)
Hox proteins are transcription factors involved in crucial processes during animal development. Their mode of action remains scantily documented. While other families of transcription factors, like Smad or Stat, are known cell signaling transducers, such a function has never been

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