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H0292

Sigma-Aldrich

HIV-1 Tat Protein (47-57)

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Empirical Formula (Hill Notation):
C64H118N32O14
CAS Number:
191936-91-1
Molecular Weight:
1559.83
MDL number:
MFCD07366706
UNSPSC Code:
12352202
PubChem Substance ID:
329815111
NACRES:
NA.32

biological source

synthetic

Quality Level

200

form

lyophilized powder

solubility

deionized water: soluble

shipped in

dry ice

storage temp.

−20°C

SMILES string

NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C64H118N32O14/c65-25-3-1-11-39(89-50(101)38(13-5-27-81-59(69)70)88-48(99)34-87-49(100)37(67)33-35-19-21-36(97)22-20-35)51(102)90-40(12-2-4-26-66)52(103)91-41(14-6-28-82-60(71)72)53(104)92-43(16-8-30-84-62(75)76)55(106)95-45(23-24-47(68)98)57(108)94-42(15-7-29-83-61(73)74)54(105)93-44(17-9-31-85-63(77)78)56(107)96-46(58(109)110)18-10-32-86-64(79)80/h19-22,37-46,97H,1-18,23-34,65-67H2,(H2,68,98)(H,87,100)(H,88,99)(H,89,101)(H,90,102)(H,91,103)(H,92,104)(H,93,105)(H,94,108)(H,95,106)(H,96,107)(H,109,110)(H4,69,70,81)(H4,71,72,82)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1

InChI key

RAVVEEJGALCVIN-AGVBWZICSA-N

Related Categories

Amino Acid Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg

General description

HIV-1 trans-activator of transcription (Tat) is an 11kDa protein, which regulates HIV-1 gene expression at the level of transcription and protein synthesis. It is located in the nucleus of infected cells. HIV-1 Tat functions as a transcriptional activator for the synthesis of full-length viral RNA. It induces RNA splicing. Tat is an RNA binding protein, which particularly recognizes trans activator response element (TAR) from the HIV-1 RNA molecule.

Biochem/physiol Actions

Synthetic peptide that includes the sequence responsible for the cellular uptake of the human immunodeficiency virus-1 Tat protein, consisting of the polycationic region 49–57. The peptide is part of the protein transduction domain (PTD) and was shown to enable the introduction of nucleic acids into cells.

Physical form

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Other Notes

Lyophilized from 0.1% TFA in H2O

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
Charnay N, et al.
Retrovirology, 6(1), 74-74 (2009)
What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?
Campbell GR and Loret EP
Retrovirology, 6(1), 50-50 (2009)
The HIV-1 Tat protein enhances splicing at the major splice donor site
Mueller N, et al.
Journal of Virology, 92(14), e01855-e01817 (2018)
Roles and functions of HIV-1 Tat protein in the CNS: an overview
Bagashev A and Sawaya BE
Virology Journal, 10(1), 358-358 (2013)
Esteban Cruz et al.
Cancers, 11(6) (2019-06-27)
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