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Safety Information

GW21353

Sigma-Aldrich

Anti-ITGAX antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD11c, Anti-Integrin α X

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About This Item

MDL number:
MFCD00164621
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21353

technique(s)

western blot: suitable

NCBI accession no.

NP_000878.1

UniProt accession no.

P20702

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ITGAX(3687)

General description

ITGAX (integrin, αX), also called CD11c, belongs to the integrin superfamily of glycoproteins. It is expressed on monocytes, inflammatory macrophages, dendritic cells, and neutrophils.

Immunogen

Immunogen Sequence: GI # 4504765, sequence 287-339
Recombinant integrin α X

Application

Anti-ITGAX antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The expression of Integrin, αX (complement component 3 receptor 4 subunit) (ITGAX) on monocytes helps in establishing a CMML (chronic myelomonocytic leukemia) diagnosis. Polycystic ovary syndrome (PCOS) is associated with an increase in CD11c expression. Its expression is rare in mantle cell lymphoma (MCL) and may aid in differentiation of CD5+ B-cell neoplasms.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
039K0510

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Zhi Hua Huang et al.
The Journal of clinical endocrinology and metabolism, 98(1), E17-E24 (2012-11-03)
Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS. We tested whether polycystic ovary syndrome (PCOS) is associated with increased ATM infiltration, especially
Payal Sojitra et al.
American journal of clinical pathology, 140(5), 686-692 (2013-10-15)
To examine the utility of CD11c expression on monocytes in normal controls and patients with chronic myelomonocytic leukemia (CMML) (n = 23) with flow cytometric immunophenotyping. Twenty-three CMML samples and 10 control bone marrows submitted for lymphoma staging without evidence
Teresa S Kraus et al.
American journal of clinical pathology, 134(2), 271-277 (2010-07-28)
Flow cytometric immunophenotyping (FCI) aids in the differentiation of chronic lymphocytic leukemia (CLL) from mantle cell lymphoma (MCL); however, overlapping phenotypes may occur. CD11c expression has been reported in up to 90% of CLL cases but has rarely been reported

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