GEE70092Z
Shrimp Alkaline Phosphatase
Cytiva E70092Z, pack of 1000 U
Sign Into View Organizational & Contract Pricing
All Photos(1)
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
form
solid
shelf life
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
packaging
pack of 1000 U
manufacturer/tradename
Cytiva E70092Z
shipped in
dry ice
storage temp.
−20°C
Related Categories
General description
Shrimp alkaline phosphatase is a high specific activity, heat-labile alkaline phosphatase. Completely and irreversibly inactivated in Tris buffers at pH 8.0 to 8.5 by heating for 15 min at 65°C. No further treatment is necessary. The ALP (alkaline phosphatase) gene codes for a membrane-bound ectoenzymes that is present in four isoforms and is distributed as tissue nonspecific, intestinal, placenta, and germ cell ALP. The tissue nonspecific enzyme is ubiquitously expressed in a variety of tissues including liver, bone, kidney and is predominant in osteoblasts. Alkaline phosphatase is also known as mesenchymal stem cell antigen 1 or tissue nonspecific alkaline phosphatase.
Biochem/physiol Actions
Alkaline phosphatase hydrolyses pyrophosphate (PPi) to inorganic phosphate and thus maintains a balance between the two forms of phosphate which is highly essential for mineralization. Higher levels of serum alkaline phosphatase is found in prostate cancer. Severe TNAP deficiency refers to hypophosphatasia characterized with defective pyridoxal 5′-phosphate metabolism and skeletal hypomineralization.
Features and Benefits
- Removing 5′-phosphates from DNA and RNA.
- Easily inactivated by heat.
Analysis Note
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
The mechanism of mineralization and the role of alkaline phosphatase in health and disease.
Orimo H
Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi, 77(1), 4-12 (2010)
Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC.
Jin H, et al.
Science Signaling, 9(458), ra121-ra121 (2016)
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer.
Rao S R, et al.
British Journal of Cancer, 116(2), 227-227 (2017)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service