ligand
porcine heparin
manufacturer/tradename
Cytiva 17-0467-01
matrix
6% cross-linked agarose
particle size
45-165 μm
average diameter
90 μm
cleaning in place
5-10
working range
5-10
capacity
~2 mg binding capacity(antithrombin III/ml drained medium)
storage temp.
2-8°C
General description
Heparin Sepharose™ CL-6B with immobilized heparin is used for purifying serum proteins with affinity for heparin, primarily antithrombin III, coagulation factors and other plasma proteins.
Heparin is a highly sulphated glycosaminoglycan which serves as an anticoagulant by selectively binding antithrombin III. Heparin Sepharose™ CL-6B is a group specific adsorbent for affinity chromatography and is widely used for purifying serum proteins including coagulation factors, lipases, lipoproteins and hormone receptors. Heparin Sepharose™ CL-6B has also successfully been used for purifying of growth factors. The polyanionic structure of heparin, which serves as an analogue of DNA and RNA, has allowed purification of many types of proteins that interact with DNA or RNA, including polymerases, ligases, kinases, ribosomal proteins and some protein synthesis factors.
Heparin is a highly sulphated glycosaminoglycan which serves as an anticoagulant by selectively binding antithrombin III. Heparin Sepharose™ CL-6B is a group specific adsorbent for affinity chromatography and is widely used for purifying serum proteins including coagulation factors, lipases, lipoproteins and hormone receptors. Heparin Sepharose™ CL-6B has also successfully been used for purifying of growth factors. The polyanionic structure of heparin, which serves as an analogue of DNA and RNA, has allowed purification of many types of proteins that interact with DNA or RNA, including polymerases, ligases, kinases, ribosomal proteins and some protein synthesis factors.
Features and Benefits
- Established medium for purifying trypsin and trypsin-like serine proteases.
Analysis Note
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
Legal Information
Sepharose is a trademark of Cytiva
Storage Class
11 - Combustible Solids
Regulatory Information
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