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G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Synonym(s):

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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1 MG
CN¥1,042.64
5 MG
CN¥3,581.43
10 MG
CN¥4,848.27
25 MG
CN¥9,262.53

CN¥1,042.64

Available to ship onApril 27, 2025Details

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1 MG
CN¥1,042.64
5 MG
CN¥3,581.43
10 MG
CN¥4,848.27
25 MG
CN¥9,262.53

About This Item

Empirical Formula (Hill Notation):
C10H12Li4N5O13P3S
CAS Number:
94825-44-2
Molecular Weight:
562.98
Beilstein:
8182249
EC Number:
305-606-1
MDL number:
MFCD00135151
UNSPSC Code:
41106305
PubChem Substance ID:
24895344
NACRES:
NA.77

CN¥1,042.64

Available to ship onApril 27, 2025Details

Request a Bulk Order

Quality Level

200

Assay

≥90% (contains < 10% GDP, HPLC)

form

powder

color

white to off-white

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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Guanosine 5&#8242;-[&#947;-thio]triphosphate tetralithium salt &#8805;90% (contains &lt; 10% GDP, HPLC), powder

G8634

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

Guanosine 5&#8242;-[&#946;-thio]diphosphate trilithium salt &#8805;85% (HPLC), powder

G7637

Guanosine 5′-[β-thio]diphosphate trilithium salt

Guanosine 5&#8242;-triphosphate lithium salt ~95% (HPLC), powder

G5884

Guanosine 5′-triphosphate lithium salt

Guanosine 3&#8242;,5&#8242;-cyclic monophosphate sodium salt &#8805;99% (HPLC), powder

G6129

Guanosine 3′,5′-cyclic monophosphate sodium salt

form

powder

form

powder

form

powder

form

powder

assay

≥90% (contains < 10% GDP, HPLC)

assay

≥85% (HPLC)

assay

~95% (HPLC)

assay

≥99% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

solubility

H2O: 20 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

solubility

H2O: 100 mg/mL

solubility

H2O: 50 mg/mL

color

white to off-white

color

white

color

white

color

white

Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer[1]
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state[2]
  • to couple with G- protein α, to study its effect on kinase activity[3]

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000387141
    0000376017
    0000376016
    0000376018
    0000340487

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    Chantal Binda et al.
    The Journal of biological chemistry, 294(45), 16865-16883 (2019-10-03)
    Accumulating evidence indicates that G protein-coupled receptors (GPCRs) interact with Rab GTPases during their intracellular trafficking. How GPCRs recruit and activate the Rabs is unclear. Here, we report that depletion of endogenous L-type prostaglandin D synthase (L-PGDS) in HeLa cells
    Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway
    Sanchez BP, et al.
    Cellular Signalling, 21(9), 1444-1454 (2009)
    Rab27a is an essential component of melanosome receptor for myosin Va
    Wu X, et al.
    Molecular Biology of the Cell, 13(5), 1735-1749 (2002)
    Jing Geng et al.
    Nature communications, 12(1), 3519-3519 (2021-06-12)
    TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate
    Abhishek Chhetri et al.
    Bio-protocol, 11(8), e3995-e3995 (2021-06-15)
    (1,3)-β-d-Glucan synthase (GS) is an essential enzyme for fungal cell wall biosynthesis that catalyzes the synthesis of (1,3)-β-d-glucan, a major and vital component of the cell wall. GS is a proven target of antifungal antibiotics including FDA-approved echinocandin derivatives; however
    View All Related Papers

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