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G8415

L-Glutamic acid

Name: <SC>L</SC>-Glutamic acid
Brand: SIGMA

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

Synonym(s):

(S)-2-Aminopentanedioic acid, Glu

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About This Item

Linear Formula:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS Number:

56-86-0

Molecular Weight:

147.13

PubChem Substance ID:

24895340

eCl@ss:

32160406

UNSPSC Code:

12352209

NACRES:

NA.26

EC Number:

200-293-7

MDL number:

MFCD00002634

Beilstein/REAXYS Number:

1723801

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Properties

Product Name

L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%

biological source

non-animal source

Quality Segment

300

agency

meets EP testing specifications

assay

98.5-100.5%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

205 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

density

1.54 g/cm³ at 20 °C

anion traces

chloride (Cl^-): ≤200 ppm, sulfate (SO₄^2-): ≤200 ppm

cation traces

As: ≤1 ppm, passes test, Fe: ≤10 ppm, passes test, NH₄⁺: ≤200 ppm, passes test

application(s)

advanced drug delivery
pharmaceutical (small molecule)

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

Gene Information

Description

Application

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.

Biochem/physiol Actions

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

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Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)