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Merck
CN

G8146

Disialoganglioside GD1b

from bovine brain, ~95%, bacterial toxin receptor , lyophilized powder

Synonym(s):

Ganglioside GD1b, disialo

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About This Item

CAS Number:
19553-76-5
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00466941

Key Documents

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Product Name

Disialoganglioside GD1b from bovine brain, ~95%, lyophilized powder

SMILES string

N([C@@H]1[C@H](O[C@H]([C@H]([C@H]1O[C@H]6O[C@H]([C@H]([C@H]([C@@H]6O)O)O)CO)O)CO)O[C@@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O[C@@]4(O[C@H]([C@@H]([C@H](C4)O)N)C(O)C(O)CO[C@]5(O[C@@H]([C@H]([C@@H](C5)O)N)C(O)C(O)CO)C(=O)O)C(=O)O)O)O[C@@H]3[C@H](O[C@H]([C@@H]([C@H

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

InChI key

AIUBMTQAHKTQMI-MPGPKOMUSA-N

assay

~95%

form

lyophilized powder

storage temp.

−20°C

Quality Level

200

Related Categories

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000536708
0000510978
0000510978
0000536708
0000473184

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Vivian Marino Mazucato et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 59(4), 428-440 (2011-03-18)
The role of the mast cell-specific gangliosides in the modulation of the endocytic pathway of FcεRI was investigated in RBL-2H3 cells and in the ganglioside-deficient cell lines, E5 and D1. MAb BC4, which binds to the α subunit of FcεRI
[Case report; A case of anti-GD1b antibody positive pure motor form Guillain-Barré syndrome with good response to combined IVIg and steroid therapy].
Takeshi Fujimoto et al.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 100(6), 1651-1653 (2011-07-21)
Ricardo D Lardone et al.
Journal of neurology, neurosurgery, and psychiatry, 81(6), 629-633 (2009-12-08)
Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Thirty-four GBS patients
Seong-Hae Jeong et al.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 31(4), 326-330 (2011-09-16)
Antiganglioside antibodies are found in various neurological disorders that constitute a continuum from peripheral neuropathy to encephalitis. However, nystagmus has rarely been described in patients with ataxia associated with antiganglioside antibodies. From January 2008 to July 2009, we identified 3
Alina Serb et al.
European journal of mass spectrometry (Chichester, England), 15(4), 541-553 (2009-08-08)
Gangliosides (GGs), a large group of sialylated glycosphingolipids, are considered biomarkers of human brain development, aging and certain diseases. Determination of individual GG components in complex mixtures extracted from a human brain represents a fundamental prerequisite for correlating their specificity
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