G8035
Anti-Glial Cell-derived Neurotrophic Factor (GDNF) antibody produced in goat
IgG fraction of antiserum, lyophilized powder
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1 L
CN¥674.64
5 L
CN¥1,971.40
CN¥674.64
Available to ship onApril 27, 2025Details
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1 L
CN¥674.64
5 L
CN¥1,971.40
About This Item
CN¥674.64
Available to ship onApril 27, 2025Details
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1 of 4
This Item | CAD7977 | CAD7972 | CAD7973 |
|---|---|---|---|
| packaging pack of 4 ea | packaging pack of 4 ea | packaging pack of 4 ea | packaging pack of 4 ea |
| manufacturer/tradename Cadence Science 7969 | manufacturer/tradename Cadence Science 7977 | manufacturer/tradename Cadence Science 7972 | manufacturer/tradename Cadence Science 7973 |
| L 2 7/8 in. | L 2 7/8 in. | L 2 7/8 in. | L 2 7/8 in. |
| gauge 16 | gauge 18 × | gauge 20 | gauge 18 |
General description
The antibody neutralizes the biological activity of recombinant human GDNF.
Immunogen
recombinant human GDNF expressed in Escherichia coli.
Biochem/physiol Actions
Glial cell-derived neurotrophic factor is a potent neurotrophic factor that is important for the maintenance, regeneration and survival of specific neuronal cells including autonomic neurons, motoneurons, noradrenergic and seotonergic neurons. Additionally, it promotes the invasion and metastatic behavior of certain types of cancers by activating ERK, p38, JNK and AP-1 mediated cell signaling.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline
Preparation Note
Purified using protein G.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Mikko Airavaara et al.
Parkinsonism & related disorders, 18 Suppl 1, S143-S146 (2011-12-23)
Although initially thought to be important primarily in neural development, a number of trophic proteins have been found to have neuroprotective and neuroregenerative activity in the adult central nervous system, particularly for midbrain dopamine neurons (MDN). Neurorestoration is potentially feasible
Shelley J Allen et al.
Pharmacology & therapeutics, 138(2), 155-175 (2013-01-26)
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain. Depletion of these neurotrophic factors has been
Jing-Yuan Chuang et al.
Oral oncology, 49(12), 1103-1112 (2013-09-28)
Perineural invasion is a prominent clinical feature of various cancers, which causes difficulty in curative resection. Glial cell-derived neurotrophic factor (GDNF), a potent neurotrophic factor, plays an important role in the invasive and metastatic behavior of various cancers. The aim
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