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G7502

Sigma-Aldrich

Guanosine 5′-diphosphoglucose sodium salt

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Synonym(s):
GDP-Glc, GDP-Glucose, GDPG
Empirical Formula (Hill Notation):
C16H25N5O16P2
CAS Number:
Molecular Weight:
605.34
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)OC4OC(CO)C(O)C(O)C4O)C(O)C3O)c2N1

InChI

1S/C16H25N5O16P2.Na.H/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15;;/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28);;

InChI key

MEXITZOHWLXZKR-UHFFFAOYSA-N

Application

Guanosine 5′-diphosphoglucose (GDP-Glucose) is a nucleotide sugar donor substrate for glucosylation reactions mediated by enzymes called glucosyltransferases. GDP-Glucose provides a source of enzyme-available glucose residues for attachment to a wide range of polysaccharide structures.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Paramita Chaudhuri et al.
Biochimica et biophysica acta, 1790(5), 368-374 (2009-03-18)
Purified trehalose-6-phosphate synthase (TPS) of Saccharomyces cerevisiae was effective over a wide range of substrates, although differing with regard to their relative activity. Polyanions heparin and chondroitin sulfate were seen to stimulate TPS activity, particularly when a pyrimidine glucose nucleotide
Aaron H Liepman et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(6), 2221-2226 (2005-01-14)
Glucuronoarabinoxylan, xyloglucan, and galactomannan are noncellulosic polysaccharides found in plant cell walls. All consist of beta-linked glycan backbones substituted with sugar side chains. Although considerable progress has been made in characterizing the structure of these polysaccharides, little is known about
Joana Costa et al.
Journal of bacteriology, 189(5), 1648-1654 (2006-12-26)
The pathway for the synthesis of glucosylglycerate (GG) in the thermophilic bacterium Persephonella marina is proposed based on the activities of recombinant glucosyl-3-phosphoglycerate (GPG) synthase (GpgS) and glucosyl-3-phosphoglycerate phosphatase (GpgP). The sequences of gpgS and gpgP from the cold-adapted bacterium
Corbin J Zea et al.
Biopolymers, 79(2), 106-113 (2005-07-12)
The glycogen synthase found in Pyrococcus furiosus is a hyperthermophilic biocatalyst that transfers the glucose portion of nucleotide-diphosphoglucose onto a growing carbohydrate biopolymer chain at 80 degrees C. In contrast to the mesophilic rabbit muscle glycogen synthase, the biocatalyst from
Carlos Gustavo Baptista et al.
BMC microbiology, 15, 269-269 (2015-11-22)
Nucleotide sugar transporters (NSTs) play an essential role in translocating nucleotide sugars into the lumen of the endoplasmic reticulum and Golgi apparatus to be used as substrates in glycosylation reactions. This intracellular transport is an essential step in the biosynthesis

Articles

Enzymatic glycosyltransferase specificity challenges the one enzyme-one linkage concept.

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