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Safety Information

G7422

Sigma-Aldrich

Anti-GSDMD (126-138) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Gasdermin D Antibody, Gasdermin D Antibody - Anti-GSDMD (126-138) antibody produced in rabbit, Gsdmd Antibody, Anti-DF5L, Anti-FKSG10, Anti-GSDMDC1, Anti-Gasdermin domain-containing protein 1

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10 ML
¥3,557.12

¥3,557.12

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10 ML
¥3,557.12

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

¥3,557.12

Please contact Customer Service for Availability
Request a Bulk Order

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

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Doxorubicin Hydrochloride

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

-

form

powder

form

powder

form

solid

form

liquid

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

grade

-

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

General description

Gasdermin D (GSDMD) is also known as DFNA5L or gasdermin domain-containing 1 (GSDMDC1), belongs to the gasdermin protein family of epithelial proliferation regulators. GSDMD is expressed in upper gastrointestinal epithelium differentiating cells.

Immunogen

synthetic peptide corresponding to amino acids 126-138 of human GSDMD

Application

Anti-GSDMD (126-138) antibody produced in rabbit has been used in:
  • immunoblotting
  • CASP4/11 assay
  • cytokine enzyme?linked immunosorbent assay

Anti-GSDMD antibody produced in rabbit is suitable for western blot analysis at a working dilution of 1:500-1:2000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

GSDMD (gasdermin D) have been suggested to function in the regulation of epithelial apoptosis. GSDMD is expressed in differentiating cells. It may act as a tumor suppressor.
The absence of Gasdermin D (GSDMD), completely blocked LPS electroporation-triggered pyroptosis in studies performed on GSDMD siRNA knockdown or GSDMD knockout (both human HeLa cells and iBMDM mouse cells). It was also reported that caspase-4/11 specifically cleaves GSDMD after Asp275, results in gasdermin-N domain that bears intrinsic pyroptosis inducing activity. Furthermore, GSDMD-mediated pyroptosis participates in mature interleukin 1β (IL-1β) release without distressing its maturation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000214432
    0000214451
    0000214432
    0000214451
    0000128077

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients
    Khanova E, et al.
    Hepatology, 67(5), 1737-1753 (2018)
    Caspase-8 collaborates with caspase-11 to drive tissue damage and execution of endotoxic shock
    Mandal P, et al.
    Immunity, 49(1), 42-55 (2018)
    Immune-complexed adenovirus induce AIM2-mediated pyroptosis in human dendritic cells
    Eichholz K, et al.
    PLoS Pathogens, 12(9), e1005871-e1005871 (2016)
    Inflammatory caspase-related pyroptosis: mechanism, regulation and therapeutic potential for inflammatory bowel disease
    Yuan YY, et al.
    Gastroenterology report, 6(3), 167-176 (2018)
    Lan H Chu et al.
    Nature communications, 9(1), 996-996 (2018-03-10)
    Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response. Although extracellular LPS is sensed by TLR4 at the cell surface and triggers a transcriptional response, cytosolic LPS binds and activates non-canonical inflammasome caspases, resulting in pyroptotic cell death
    View All Related Papers

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