Skip to Content
Merck
CN
All Photos(4)

Documents

G7127

Sigma-Aldrich

Guanosine 5′-diphosphate sodium salt

Type I, ≥96% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(4)
Synonym(s):
GDP
Empirical Formula (Hill Notation):
C10H15N5O11P2
CAS Number:
43139-22-6
Molecular Weight:
443.20
MDL number:
MFCD00070121
UNSPSC Code:
41106305
PubChem Substance ID:
24895291
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

300

type

Type I

Assay

≥96% (HPLC)

form

powder

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O)c2N1

InChI

1S/C10H15N5O11P2.Na.H/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;

InChI key

PVMPTWQLNDHIEV-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Guanosine 5′-diphosphate sodium salt has been used:
  • in GTP-γ-35S functional assays
  • in Y1 agonist-stimulated [35S]- guanosine-5′-O-(3-thio)triphosphate (GTPγS) functional binding
  • in the expression and purification of recombinant proteins

Biochem/physiol Actions

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT 1A agonist, as a putative mediator of quetiapine's antidepressant activity
Jensen N H, et al.
Neuropsychopharmacology, 33(10), 2303-2303 (2008)
Neuropeptide Y promotes neurogenesis in murine subventricular zone
Agasse F, et al.
Stem Cells, 26(6), 1636-1645 (2008)
María-de-Los-Angeles Andrade-Oliva et al.
Environmental toxicology and pharmacology, 60, 58-65 (2018-04-17)
Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3). In membranes from rat prefrontal cortex
Nicola M Martucci et al.
Biochimie, 94(2), 503-509 (2011-09-20)
The effect of pulvomycin on the biochemical and fluorescence spectroscopic properties of the archaeal elongation factor 1α from Sulfolobus solfataricus (SsEF-1α), the functional analog of eubacterial EF-Tu, was investigated. The antibiotic was able to reduce in vitro the rate of protein
Nami Kim et al.
Scientific reports, 7, 41066-41066 (2017-01-25)
This study characterizes the human metabolic response to piperine, a curcumin extract, and the details of its underlying molecular mechanism. Using
View All Related Papers

Protocols

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service