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G6761

Sigma-Aldrich

Glycine sodium salt hydrate

≥99% (HPLC)

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About This Item

Linear Formula:
H2NCH2CO2Na · xH2O
CAS Number:
207300-76-3
Molecular Weight:
97.05 (anhydrous basis)
MDL number:
MFCD00150683
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895270
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

300

Assay

≥99% (HPLC)

form

powder

mol wt

97.05 g/mol (anhydrous basis)

technique(s)

electrophoresis: suitable

mp

197-201 °C (lit.)

SMILES string

[Na+].[H]O[H].NCC([O-])=O

InChI

1S/C2H5NO2.Na.H2O/c3-1-2(4)5;;/h1,3H2,(H,4,5);;1H2/q;+1;/p-1

InChI key

CIJQGPVMMRXSQW-UHFFFAOYSA-M

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General description

Research area: Neuroscience

Glycine is a simple non-essential amino acidIt is synthesized from choline, threonine and serine. It serves as a precursor for porphyrins, purines, glutathione and creatine.

Application

Glycine sodium salt hydrate has been used as a component of buffer for homogenization of whole muscle for protein extraction and in electrophoresis buffer. It has also been used as a neurotransmitter in immunohistochemical staining of Zebrafish spinal cord sections.

Biochem/physiol Actions

Glycine serves as a neurotransmitter in the central nervous system. It aids in increasing the quality of sleep and neurological functions. It is essential for the regulation immune function, metabolism, growth and development. Glycine modulates intracellular Ca2+ levels and cytokines production. Studies have shown that glycine treatment effectively prevents organ transplantation failure by mitigating ischemia reperfusion injury caused by cold ischemic storage. Additionally, glycine treatment also enhances graft function during transplantation. A reduction in glycine levels is observed in obesity, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLDs). Glycine is degraded to serine by glycine serine hydroxymethyltransferase 1 in cytoplasm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000415501
0000412448
0000415499
0000415501
0000412448

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Multifarious beneficial effect of nonessential amino acid, glycine: a review
Razak MA, et al.
Oxidative Medicine and Cellular Longevity, 2017 (2017)
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
Alves A, et al.
Nutrients, 11(6), 1356-1356 (2019)
Phylogenetic relationships among five marine Catfish species (Pisces: Ariidae) from Mexico
Tenorio-Colin G, et al.
Hidrobiologica, 20(3), 266-274 (2010)
Complementary expression of calcium binding proteins delineates the functional organization of the locomotor network
Berg EM, et al.
Brain Structure &Amp; Function, 223(5), 2181-2196 (2018)
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review
Razak MA, et al.
Oxidative Medicine and Cellular Longevity (2017)
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