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Merck
CN

G6132

Glycodeoxycholic acid monohydrate

≥97% (TLC)

Synonym(s):

3α,12α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Linear Formula:
C26H43NO5
CAS Number:
Molecular Weight:
467.64
PubChem Substance ID:
UNSPSC Code:
12161900
Beilstein/REAXYS Number:
2954947
MDL number:
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SMILES string

[H]O[H].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.H2O/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);1H2/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;/m1./s1

InChI key

DLOTUJUSJVIXDW-YEUHZSMFSA-N

description

anionic

assay

≥97% (TLC)

Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Sandeep Khurana et al.
PloS one, 7(2), e32006-e32006 (2012-02-24)
Bile acids (BAs) regulate cardiovascular function via diverse mechanisms. Although in both health and disease serum glycine-conjugated BAs are more abundant than taurine-conjugated BAs, their effects on myogenic tone (MT), a key determinant of systemic vascular resistance (SVR), have not
Kai A Bachmann et al.
Critical care (London, England), 17(6), R281-R281 (2013-12-10)
Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, microcirculation, tissue oxygenation and histopathologic damage in an experimental
Lutz Schneider et al.
Pancreas, 38(6), 676-680 (2009-07-25)
Calcitonin gene-related peptide (CGRP) is released from perivascular pancreatic nerves. It effects vasomotion and cytokine liberation in inflammatory processes, including acute pancreatitis (AP). Calcitonin gene-related peptide liberation is stimulated by capsaicin, a substance of red hot chili peppers. Aim of
Jesper Østergaard et al.
Journal of separation science, 32(10), 1712-1721 (2009-05-28)
The practical and theoretical problems associated with interpretation of binding isotherms obtained by the investigation of weak analyte-ligand interactions using mobility shift affinity CE were investigated with special emphasis on various correction methods to compensate for media effects due to
Yong Zhou et al.
American journal of physiology. Gastrointestinal and liver physiology, 298(5), G722-G731 (2010-03-06)
The injurious effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the small intestine was not appreciated until the widespread use of capsule endoscopy. Animal studies found that NSAID-induced small intestinal injury depends on the ability of these drugs to be secreted

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