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G5261

Sigma-Aldrich

Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide

≥95% (HPLC)

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Synonym(s):
H-Gly-Asp-Asp-Asp-Asp-Lys-bNA
Empirical Formula (Hill Notation):
C34H44N8O14
CAS Number:
70023-02-8
Molecular Weight:
788.76
MDL number:
MFCD00083712
UNSPSC Code:
12352204
PubChem Substance ID:
24895202
NACRES:
NA.32

Quality Level

200

Assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

NCCCCC(NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CC(O)=O)NC(=O)CN)C(=O)Nc1ccc2ccccc2c1

InChI

1S/C34H44N8O14/c35-10-4-3-7-20(30(52)37-19-9-8-17-5-1-2-6-18(17)11-19)39-32(54)22(13-27(46)47)41-34(56)24(15-29(50)51)42-33(55)23(14-28(48)49)40-31(53)21(12-26(44)45)38-25(43)16-36/h1-2,5-6,8-9,11,20-24H,3-4,7,10,12-16,35-36H2,(H,37,52)(H,38,43)(H,39,54)(H,40,53)(H,41,56)(H,42,55)(H,44,45)(H,46,47)(H,48,49)(H,50,51)

InChI key

QLLWULMEPVZWTP-UHFFFAOYSA-N

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Substrates

A sensitive and specific fluorogenic substrate for enterokinase.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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I Antonowicz et al.
Clinica chimica acta; international journal of clinical chemistry, 101(1), 69-76 (1980-02-14)
The application of a new synthetic substrate to the direct determination of enteropeptidase is described. The substrate Gly-(L-Asp)4-L-Lys-2-naphthylamide contains the amino acid sequence of the activation peptides of trypsinogen linked via an amide bond to the fluorophore 2-naphthylamine. The sequence
Weimei Sun et al.
The Journal of pharmacology and experimental therapeutics, 375(3), 510-521 (2020-10-10)
Inhibition of the serine protease enteropeptidase (EP) opens a new avenue to the discovery of chemotherapeutics for the treatment of metabolic diseases. Camostat has been used clinically for treating chronic pancreatitis in Japan; however, the mechanistic basis of the observed

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