G4671
Anti-GATA1 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~42 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... GATA1(2623)
mouse ... Gata1(14460)
rat ... Gata1(25172)
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Immunogen
synthetic peptide corresponding to residues 211-225 of human GATA1.
Application
Anti-GATA1 antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:500 to 1:1000 and for immunohistochemistry at a working dilution of 1:100 to 1:250.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
GATA1 belongs to the GATA family of transcription factors. The encoded protein regulates erythroid development and megakaryocyte differentiation. It binds to the consensus sequence 5′-[AT]GATA[AG]-3′ within the regulatory region. Defects in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Reduced levels of GATA1 may cause Diamond-Blackfan anemia.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
related product
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
C D Trainor et al.
Nature, 343(6253), 92-96 (1990-01-04)
Vertebrate erythroid cells contain a tissue-specific transcription factor referred to as Eryf 1 (ref. 1), GF-1 (ref. 2) or NF-E1 (ref. 3), for which binding sites are widely distributed in the promoters and enhancers of the globin gene family, and
Luciana M Hollanda et al.
Nature genetics, 38(7), 807-812 (2006-06-20)
Acquired somatic mutations in exon 2 of the hematopoietic transcription factor GATA-1 have been found in individuals with Down syndrome with both transient myeloproliferative disorder and acute megakaryoblastic leukemia. These mutations prevent the synthesis of the full-length protein but allow
Leif S Ludwig et al.
Nature medicine, 20(7), 748-753 (2014-06-24)
Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA), congenital asplenia and T cell leukemia. Yet, how mutations in genes encoding ubiquitously expressed proteins such as these result in cell-type- and tissue-specific defects remains unknown. Here, we
K E Nichols et al.
Nature genetics, 24(3), 266-270 (2000-03-04)
Haematopoietic development is regulated by nuclear protein complexes that coordinate lineage-specific patterns of gene expression. Targeted mutagenesis in embryonic stem cells and mice has revealed roles for the X-linked gene Gata1 in erythrocyte and megakaryocyte differentiation. GATA-1 is the founding
Fengyun Sun et al.
Development (Cambridge, England), 137(10), 1699-1707 (2010-05-01)
The ENU-induced repro8 mutation was identified in a screen to uncover genes that control mouse gametogenesis. repro8 causes male-limited infertility, with failure of spermatocytes to exit meiotic prophase via the G2/MI transition. The repro8 mutation is in the Eif4g3 gene
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