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G4256

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast

Type IV, lyophilized powder, 20-60 units/mg protein (modified Warburg-Christian)

Synonym(s):

GALT, UDP glucose:α-D-galactose-1-phosphate uridyltransferase

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About This Item

CAS Number:
9016-11-9
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
2.7.7.12 (BRENDA, IUBMB)
MDL number:
MFCD00131120

Key Documents

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Product Name

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast, Type IV, lyophilized powder, 20-60 units/mg protein (modified Warburg-Christian)

type

Type IV

form

lyophilized powder

specific activity

20-60 units/mg protein (modified Warburg-Christian)

composition

Protein, 15-35%

foreign activity

6-phosphogluconate dehydrogenase ≤0.5%
UDP glucose pyrophosphorylase and galactokinase ≤0.2%

storage temp.

−20°C

Quality Level

300

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Application

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast has been used to perform enzyme assays.

General description

Research area: Cell Signaling

Galactose-1-phosphate uridyltransferase (GALT) is a galactose metabolizing enzyme that facilitates the simultaneous conversion of uridine diphosphoglucose (UDP-glucose) and galactose-1-phosphate (gal-1P) to uridine diphosphogalactose (UDP-galactose) and glucose-1-phosphate. Classic Galactosemia (CG) is an inherited metabolic condition caused by deficiency of GALT activity. GALT gene is mapped to human chromosome 9p13. Deficiency of GALT results in type 1 galactosemia.

Other Notes

One unit will form 1.0 μmole of glucose 1-phosphate from UDP-glucose, galactose 1-phosphate and NADP+ per min at pH 8.7 at 25 °C as detected by a coupled system using phosphoglucomutase.

Physical form

Contains buffer salts as citrate and reduced glutathione

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000430616
0000430615
0000328731
0000430616
0000430615

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Ji-Seon Jeong et al.
Journal of chromatography. A, 1140(1-2), 157-162 (2006-12-13)
We developed a new non-derivatization analytical method for the determination of galactose in the diagnosis of galactosemia by high-performance anion-exchange chromatography (HPAEC)-pulsed amperometric detection (PAD). With an anion-exchange column, the analytes were separated efficiently using 3mM NaOH containing 1mM NaOAc
Galactose 1-phosphate uridylyltransferase. Isolation of a uridylyl-enzyme intermediate.
L J Wong et al.
The Journal of biological chemistry, 249(7), 2322-2324 (1974-04-10)
E Laumonier et al.
Journal francais d'ophtalmologie, 28(5), 490-496 (2005-06-25)
Galactosemia is an inherited metabolic disorder due to a defect in one of the three enzymes required to fully metabolize the galactose in glucose: the galactose 1-phosphate uridyltransferase. Because this enzyme is present in the normal foetal liver since the
Ana C Bonatto et al.
Protein expression and purification, 55(2), 293-299 (2007-06-08)
GlnD is a bifunctional uridylyltransferase/uridylyl-removing enzyme that has a central role in the general nitrogen regulatory system NTR. In enterobacteria, GlnD uridylylates the PII proteins GlnB and GlnK under low levels of fixed nitrogen or ammonium. Under high ammonium levels
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