form
lyophilized powder
Quality Level
color
white
solubility
1% acetic acid: 1 mg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GHRL(51738)
Amino Acid Sequence
Gly-Ser-Ser(O-n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
General description
Ghrelin is a gastric acyl-peptide or an orexigenic digestive hormone. It is synthesized by the ghrelin producing cells in the gastric oxyntic mucosa. GHRL gene is mapped to human chromosome 3p25-p26.
Application
Ghrelin human has been used to study the influence of leptin and ghrelin on secretory function of equine corpus luteum (CL) in vitro.
Biochem/physiol Actions
Ghrelin participates in cell proliferation. It plays a major role in sleep and memory. Ghrelin is also associated with depression, especially for particular endophenotypes. It promotes growth hormone (GH) release in central nervous system.
Endogenous ligand to the orphan growth-hormone secretagogue receptor that stimulates the release of growth hormone from the pituitary.
Physical form
Lyophilized from 0.1% aqueous TFA
Other Notes
Lyophilized from 0.1% TFA in H2O
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
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Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin
Mantero P, et al.
World Journal of Gastroenterology, 24(3), 397-397 (2018)
The effects of ghrelin on sleep, appetite, and memory, and its possible role in depression: A review of the literature
Morin V, et al.
Encephale (2018)
Ghrelin promotes human non-small cell lung cancer A549 cell proliferation through PI3K/Akt/mTOR/P70S6K and ERK signaling pathways
Zhu J, et al.
Biochemical and biophysical research communications, 498(3), 616-620 (2018)
Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study
Galvao A, et al.
Mediators of Inflammation, 2014(2) (2014)
Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes
Dantas V G L, et al.
Genetics and Molecular Biology, 34(2), 205-207 (2011)
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