G3882
Gly-Gly-Gly-Gly
≥98% (TLC)
Synonym(s):
Glycyl-glycyl-glycyl-glycine, Tetraglycine, Triglycyl-glycine
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About This Item
Linear Formula:
NH2CH2CO(NHCH2CO)3OH
CAS Number:
Molecular Weight:
246.22
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
211-303-4
MDL number:
Beilstein/REAXYS Number:
1715387
Product Name
Gly-Gly-Gly-Gly,
InChI key
QMOQBVOBWVNSNO-UHFFFAOYSA-N
InChI
1S/C8H14N4O5/c9-1-5(13)10-2-6(14)11-3-7(15)12-4-8(16)17/h1-4,9H2,(H,10,13)(H,11,14)(H,12,15)(H,16,17)
SMILES string
NCC(=O)NCC(=O)NCC(=O)NCC(O)=O
assay
≥98% (TLC)
form
powder
color
white to off-white
mp
300 °C
application(s)
peptide synthesis
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Tetraglycine is used with copper (Cu-II) to study mechanisms of hydrogen peroxide/bicarbonate free radical production and effect in vitro.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Fabian Barthels et al.
ChemMedChem, 15(10), 839-850 (2020-03-03)
Staphylococcus aureus is one of the most frequent causes of nosocomial and community-acquired infections, with drug-resistant strains being responsible for tens of thousands of deaths per year. S. aureus sortase A inhibitors are designed to interfere with virulence determinants. We
María V Alipázaga et al.
Dalton transactions (Cambridge, England : 2003), (13)(13), 2036-2040 (2004-07-15)
The synergistic effect of Ni(II) and Co(II) on the sulfite induced autoxidation of Cu(II)/tetraglycine was investigated spectrophotometrically at 25.0 degrees C, pH = 9.0, 1 x 10(-5) mol dm(-3) < or = [S(IV)] < or = 8 x 10(-5) mol
Udo H Verkerk et al.
The journal of physical chemistry. A, 115(24), 6683-6687 (2011-05-21)
Collision-induced dissociations of protonated (18)O-labeled tetraglycines labeled separately at either the first or the second amide bond established that water loss from the backbone occurs from the N-terminal residue. Density functional theory at B3LYP/6-311++G(d,p) predicted that the low-energy [G(4) +
Yanfeng Yao et al.
Emerging microbes & infections, 8(1), 45-54 (2019-03-15)
Current influenza vaccines provide hemagglutinin strain-specific protection, but rarely provide cross-protection against divergent strains. It is, therefore, particularly important to develop a universal vaccine against conserved proteins or conserved regions of the virus. In this study, we used N-terminal extracellular
K S Kasprzak et al.
Carcinogenesis, 10(3), 621-624 (1989-03-01)
This study was undertaken to explore whether nuclear chromatin constituents can participate in and/or be affected by redox reactions catalyzed by nickel, like those of nickel complexes with small peptides, e.g. tetraglycine (G4) and oxygen. Calf thymus DNA, nucleohistone (NH)
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