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G1513

Sigma-Aldrich

Glycerol formal

47-67% 5-hydroxy-1,3-dioxane basis (GC), 33-53% 4-hydroxymethyl-1,3-dioxolane basis (GC)

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Empirical Formula (Hill Notation):
C4H8O3
CAS Number:
99569-11-6
Molecular Weight:
104.10
Beilstein:
103206
MDL number:
MFCD10039829
UNSPSC Code:
50161901
PubChem Substance ID:
24895065
NACRES:
NA.25

Quality Level

200

contains

~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer

composition

5-hydroxy-1,3-dioxane, 47-67% GC
4-hydroxymethyl-1,3-dioxolane, 33-53% GC

refractive index

n20/D 1.451 (lit.)

bp

192-193 °C (lit.)

density

1.203 g/mL at 25 °C (lit.)

SMILES string

OCC1COCO1.OC2COCOC2

InChI

1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2

InChI key

JIUMSISXCKWZTA-UHFFFAOYSA-N

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General description

Glycerol formal (GlyF) includes isomers, namely, 4-hydroxymethyl-1,3-dioxolane and 5-hydroxy-1,3-dioxane. It is a glycerol synthon with a combination of two 5- and 6-membered ring isomers.

Application

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Properties of fatty acid glycerol formal ester (FAGE) for use as a component in blends for diesel engines
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Biomass and Bioenergy, 130-140 (2015)
Selective catalytic etherification of glycerol formal and solketal with dialkyl carbonates and K 2 CO 3
Selva M, et al.
Green Chemistry, 188-200 (2012)
Sarah Nickolls et al.
Advances in pharmacological sciences, 2011, 608912-608912 (2011-12-14)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range
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Anticancer research, 35(9), 4681-4689 (2015-08-09)
We investigated whether hepatic multidrug resistance-associated protein 2 (ABCC2) is involved in the hepatobiliary excretion of regorafenib, a novel multi-kinase inhibitor, using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR) lacking the efflux transporter ABCC2. The involvement of organic anion-transporting

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