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G1376

Sigma-Aldrich

L-Glutamic acid ammonium salt

≥99% (TLC)

Synonym(s):

(S)-2-Aminopentanedioic acid ammonium salt, Glu

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About This Item

Linear Formula:
C5H8NO4 · NH4
CAS Number:
Molecular Weight:
164.16
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

Assay

≥99% (TLC)

SMILES string

N.NC(CCC(O)=O)C(O)=O

Biochem/physiol Actions

Agonist at kainate, NMDA, and quisqualate glutamatergic receptors; an excitatory amino acid neurotransmitter.
L-Glutamic acid is a natural α proteinogenic amino acid use in a wide range of research application including use as a cell culture supplement, enzyme substrate or receptor ligand. L-Glutamine is an agonist at kainate, NMDA, and quisqualate glutamatergic receptors and an excitatory amino acid neurotransmitter.

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Sandra Stoppelkamp et al.
Journal of neuroscience methods, 194(1), 132-138 (2010-10-19)
The cultivation of pure neuronal cultures is considered advantageous for the investigation of cell-type specific responses (such as transmitter release and also pharmacological agents), however, divergent results are a likely consequence of media modifications and culture composition. Using Fura-2 based
M E Flores-Soto et al.
Neurologia (Barcelona, Spain), 27(5), 301-310 (2012-01-06)
To review the physiology of the glutamate receptor subunits such as N-methyl-D-aspartate (NMDA). Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system which interacts with two types classified into two types: metabotropic and ionotropic. Ionotropic receptors
K Sugiyama et al.
Neuroscience, 32(3), 779-791 (1989-01-01)
Several reports have described apparently normal survival and development of hippocampal and spinal cord culture preparations grown in Ham's F-12 medium, which contains 100 microM each of L-glutamate and L-aspartate. As at this concentration these amino acids are neurotoxic, some
Jennifer C M Lau et al.
Molecular vision, 19, 1538-1553 (2013-07-24)
This study investigated changes in the transcript levels of genes related to glutamate neurotransmission and transport as diabetes progresses in the Long-Evans rat retina. Transcript levels of vascular endothelial growth factor (VEGF), erythropoietin, and insulin-like growth factor binding protein 3
Yohei Okubo
Brain and nerve = Shinkei kenkyu no shinpo, 65(6), 651-658 (2013-06-06)
Glutamate is the major excitatory neurotransmitter in the mammalian brain. The conventional view is that glutamate mediates synaptically confined point-to-point transmission at excitatory synapses. However, glutamate has also been suggested to escape from the synaptic cleft and mediate volume transmission

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