All Photos(1)
Synonym(s):
(S)-2-Aminopentanedioic acid ammonium salt, Glu
Linear Formula:
C5H8NO4 · NH4
CAS Number:
Molecular Weight:
164.16
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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Assay
≥99% (TLC)
SMILES string
N.NC(CCC(O)=O)C(O)=O
Biochem/physiol Actions
L-Glutamic acid is a natural α proteinogenic amino acid use in a wide range of research application including use as a cell culture supplement, enzyme substrate or receptor ligand. L-Glutamine is an agonist at kainate, NMDA, and quisqualate glutamatergic receptors and an excitatory amino acid neurotransmitter.
Agonist at kainate, NMDA, and quisqualate glutamatergic receptors; an excitatory amino acid neurotransmitter.
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M E Flores-Soto et al.
Neurologia (Barcelona, Spain), 27(5), 301-310 (2012-01-06)
To review the physiology of the glutamate receptor subunits such as N-methyl-D-aspartate (NMDA). Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system which interacts with two types classified into two types: metabotropic and ionotropic. Ionotropic receptors
K Sugiyama et al.
Neuroscience, 32(3), 779-791 (1989-01-01)
Several reports have described apparently normal survival and development of hippocampal and spinal cord culture preparations grown in Ham's F-12 medium, which contains 100 microM each of L-glutamate and L-aspartate. As at this concentration these amino acids are neurotoxic, some
Sandra Stoppelkamp et al.
Journal of neuroscience methods, 194(1), 132-138 (2010-10-19)
The cultivation of pure neuronal cultures is considered advantageous for the investigation of cell-type specific responses (such as transmitter release and also pharmacological agents), however, divergent results are a likely consequence of media modifications and culture composition. Using Fura-2 based
Jennifer C M Lau et al.
Molecular vision, 19, 1538-1553 (2013-07-24)
This study investigated changes in the transcript levels of genes related to glutamate neurotransmission and transport as diabetes progresses in the Long-Evans rat retina. Transcript levels of vascular endothelial growth factor (VEGF), erythropoietin, and insulin-like growth factor binding protein 3
Tamara Perez-Rosello et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(22), 9259-9272 (2013-05-31)
Although it is well established that many glutamatergic neurons sequester Zn(2+) within their synaptic vesicles, the physiological significance of synaptic Zn(2+) remains poorly understood. In experiments performed in a Zn(2+)-enriched auditory brainstem nucleus--the dorsal cochlear nucleus--we discovered that synaptic Zn(2+)
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