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Merck
CN

G1171

Gö 6976

≥98% (HPLC), powder

Synonym(s):

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976

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About This Item

Empirical Formula (Hill Notation):
C24H18N4O
CAS Number:
136194-77-9
Molecular Weight:
378.43
UNSPSC Code:
12352200
PubChem Substance ID:
329799832
MDL number:
MFCD00236434

Key Documents

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InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

SMILES string

Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

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Application

Gö 6976 has been used:
  • as an inhibitor of protein kinase C (PKC) in mammalian cell lines
  • as a PKCμ inhibitor in oocytes
  • as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels

Biochem/physiol Actions

Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.
Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122M4710V
022M4702V
061M4721V
061M4702V
110M4710V

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Katherine A Robinson et al.
PloS one, 9(10), e108963-e108963 (2014-10-21)
Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concentrations. We have previously shown that the mTOR complex
Hairuo Wen et al.
Journal of neurochemistry, 108(2), 331-340 (2008-12-03)
The potentiation of P2X(1) receptor currents by phorbol ester (PMA) treatment and stimulation of mGluR1alpha receptors was sensitive to inhibition of novel forms of protein kinase C. Potentiation was also reduced by co-expression of an amino terminal P2X(1) receptor minigene.
Shaon Naskar et al.
PloS one, 9(8), e104711-e104711 (2014-08-15)
A cardiac hypertrophy is defined as an increase in heart mass which may either be beneficial (physiological hypertrophy) or detrimental (pathological hypertrophy). This study was undertaken to establish the role of different protein kinase-C (PKC) isoforms in the regulation of
Sune T Jørgensen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 31(2-3), 366-378 (2013-03-15)
Signalling via CysLT1 is involved in activation of volume sensitive K(+) channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD). The aim is to illustrate the effect of mutation of putative PKC consensus phosphorylation sites in
Qian Zhang et al.
American journal of physiology. Renal physiology, 304(3), F326-F332 (2012-12-12)
Tubuloglomerular feedback (TGF)-mediated constriction of the afferent arteriole is modulated by a balance between release of superoxide (O(2)(-)) and nitric oxide (NO) in macula densa (MD) cells. Aldosterone activates mineralocorticoid receptors that are expressed in the MD and induces both
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