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Safety Information

G0419

Sigma-Aldrich

GR 55562 dihydrobromide

>97% (HPLC), powder

Synonym(s):

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
172854-55-6
Molecular Weight:
537.29
MDL number:
MFCD06201848
UNSPSC Code:
12352202

description

Store tightly sealed with desiccant.

Assay

>97% (HPLC)

form

powder

color

light yellow

solubility

H2O: ~12 mg/mL (with mixing)

storage temp.

2-8°C

InChI

1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H

InChI key

NUDSRNNZTVHCKY-UHFFFAOYSA-N

Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
093K4623

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M Filip et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 52(2), 249-263 (2001-07-17)
Mesolimbic dopamine pathways play a critical role in the behavioural effects of cocaine in rodents. Nonetheless, research has also demonstrated involvement of 5-hydroxytryptamine (5-HT; serotonin) transmission in these effects. The present study investigated the ability of selective 5-HT1B receptor ligands
M R MacLean et al.
British journal of pharmacology, 119(2), 277-282 (1996-09-01)
1. The 5-hydroxytryptamine (5-HT) receptors mediating contraction of human isolated pulmonary artery rings were investigated. Responses to the agonists 5-carboximidotryptamine (5-CT, non-selective 5-HT1 agonist), sumatriptan (5-HT1D-like receptor agonist), 5-HT and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, 5-HT1A receptor agonist) were studied. Responses to 5-HT
Ji-Hyun Kim et al.
Pharmacology, biochemistry, and behavior, 87(1), 41-47 (2007-05-05)
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h
E Przegaliński et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 53(3), 383-394 (2002-10-09)
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 12(5), 387-396 (2002-09-05)
The present study was designed to find out whether 5-HT(1B) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar
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