G0290
Anti-GATA1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-ERYF1, Anti-Erythroid transcription factor 1, Anti-Globin transcription factor 1
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 45 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
technique(s)
microarray: suitable
western blot: 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GATA1(2623)
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General description
GATA is an important cis-element factor in the haematopoietic lineage belongs to GATA-binding protein family. It was first identified in the analysis of globin gene promoters and enhancers. There are different types of GATA proteins: GATA-1, GATA-2, GATA-3. It is expressed in erythroid, mast, megakaryocytic lineages, multipotential progenitor cells and lines.
GATA-1 (ERYF1, GF-1, NF-1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells.
Immunogen
synthetic peptide corresponding to the C-terminal region of human GATA-1 (amino acids 394-413).
Application
Anti-GATA1 antibody produced in rabbit has been used in gel mobility shift assay and DNase I footprinting. It has also been used in confocal microscopy analysis.
Biochem/physiol Actions
GATA is a lineage-restricted transcription factor which plays a pivotal role in erythroid differentiation. It possesses potential binding sites in the regulatory sequences of all erythroid genes. GATA is expressed at higher levels during erythroid maturation. It is essential for terminal differentiation of erythrocytes and megakaryocytes and associated in vivo with the acetyl transferase p300/CBP. Mutation in GATA1 causes thrombocytopenia and abnormal platelet function.
GATA-binding factor 1 (GATA-1) is involved in blocking apoptosis of precursor cells and in controlling the balance between proliferation and cell cycle arrest.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
含少量动物源组分生物产品
Certificates of Analysis (COA)
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M E Cullen et al.
The Journal of biological chemistry, 272(4), 2464-2469 (1997-01-24)
We have set out to test a model for tissue-specific gene expression that relies on the early replication of expressed genes to sequester limiting activating transcription factors. Using an erythroid cell line, we have tested the changes in the DNA
Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages
Martin Dik, et al.
Nature, 344(6265), 444-444 (1990)
Chromatin structure at the flanking regions of the human beta-globin locus control region DNase I hypersensitive site-2: proposed nucleosome positioning by DNA-binding proteins including GATA-1
Davies N, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1679(3), 201-213 (2004)
CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
Blobel GA, et al.
Proceedings of the National Academy of Sciences of the USA, 95(5), 2061-2066 (1998)
Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis
Kadri Z, et al.
Genes & Development, 29(24), 2603-2616 (2015)
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