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G0141

Sigma-Aldrich

L-Glutamic acid γ-(4-methoxy-β-naphthylamide)

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Empirical Formula (Hill Notation):
C16H18N2O4
CAS Number:
24723-50-0
Molecular Weight:
302.33
MDL number:
MFCD00037728
UNSPSC Code:
12352204
PubChem Substance ID:
24895008
NACRES:
NA.83

Assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

1 N HCl: ethanol, 1:1: 25 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

OC([C@@H](N)CCC(NC1=CC2=CC=CC=C2C(OC)=C1)=O)=O

InChI

1S/C16H18N2O4/c1-22-14-9-11(8-10-4-2-3-5-12(10)14)18-15(19)7-6-13(17)16(20)21/h2-5,8-9,13H,6-7,17H2,1H3,(H,18,19)(H,20,21)

InChI key

DUNDTSUHZJULAX-UHFFFAOYSA-N

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Application

L-Glutamic acid γ-(4-methoxy-β-naphthylamide) has been used in histochemical staining of HepG2 cells for γ-glutamyl transpeptidase (GGT) subcellular localization.

Biochem/physiol Actions

L-Glutamic acid γ-(4-methoxy-β-naphthylamide) or GMNA is a synthetic substrate of γ-glutamyl transpeptidase (GGT).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Aflatoxin B~ 1 and 2-acetylaminofluorene induced hepatic carcinogenicity and gamma-glutamyltranspeptidase expression via chronic feeding in rats
Liao JW, et al.
The American Journal of Medicine, 44(1) , 37-50 (2002)
Matthew B West et al.
Archives of biochemistry and biophysics, 504(2), 177-181 (2010-09-14)
The cell surface enzyme γ-glutamyl transpeptidase (GGT) is expressed by human hepatocellular carcinomas (HCCs). HCCs arise from malignant transformation of hepatocytes and are the most common form of primary liver cancer. Identification of tumor-specific, post-translational modifications of GGT may provide
Carlos David López-Torres et al.
The journal of gene medicine, 24(8), e3439-e3439 (2022-07-12)
Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide, often preceded by cirrhosis and usually diagnosed at advanced stages; therefore, identifying molecular changes at early stages is an attractive strategy for detection and timely treatment. Here, we investigated the
Fatima Dahboul et al.
PloS one, 7(9), e43190-e43190 (2012-09-18)
S-nitrosoglutathione (GSNO) involved in storage and transport of nitric oxide ((•)NO) plays an important role in vascular homeostasis. Breakdown of GSNO can be catalyzed by γ-glutamyltransferase (GGT). We investigated whether vascular GGT influences the vasorelaxant effect of GSNO in isolated

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