G0141
L-Glutamic acid γ-(4-methoxy-β-naphthylamide)
≥98% (TLC), powder
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About This Item
Empirical Formula (Hill Notation):
C16H18N2O4
CAS Number:
Molecular Weight:
302.33
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
MDL number:
Product Name
L-Glutamic acid γ-(4-methoxy-β-naphthylamide),
SMILES string
OC([C@@H](N)CCC(NC1=CC2=CC=CC=C2C(OC)=C1)=O)=O
InChI
1S/C16H18N2O4/c1-22-14-9-11(8-10-4-2-3-5-12(10)14)18-15(19)7-6-13(17)16(20)21/h2-5,8-9,13H,6-7,17H2,1H3,(H,18,19)(H,20,21)
InChI key
DUNDTSUHZJULAX-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
1 N HCl: ethanol, 1:1: 25 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
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Application
L-Glutamic acid γ-(4-methoxy-β-naphthylamide) has been used in histochemical staining of HepG2 cells for γ-glutamyl transpeptidase (GGT) subcellular localization.
Biochem/physiol Actions
L-Glutamic acid γ-(4-methoxy-β-naphthylamide) or GMNA is a synthetic substrate of γ-glutamyl transpeptidase (GGT).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Matthew B West et al.
Archives of biochemistry and biophysics, 504(2), 177-181 (2010-09-14)
The cell surface enzyme γ-glutamyl transpeptidase (GGT) is expressed by human hepatocellular carcinomas (HCCs). HCCs arise from malignant transformation of hepatocytes and are the most common form of primary liver cancer. Identification of tumor-specific, post-translational modifications of GGT may provide
Aflatoxin B~ 1 and 2-acetylaminofluorene induced hepatic carcinogenicity and gamma-glutamyltranspeptidase expression via chronic feeding in rats
Liao JW, et al.
The American Journal of Medicine, 44(1)
, 37-50
(2002)
Carlos David López-Torres et al.
The journal of gene medicine, 24(8), e3439-e3439 (2022-07-12)
Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide, often preceded by cirrhosis and usually diagnosed at advanced stages; therefore, identifying molecular changes at early stages is an attractive strategy for detection and timely treatment. Here, we investigated the
Fatima Dahboul et al.
PloS one, 7(9), e43190-e43190 (2012-09-18)
S-nitrosoglutathione (GSNO) involved in storage and transport of nitric oxide ((•)NO) plays an important role in vascular homeostasis. Breakdown of GSNO can be catalyzed by γ-glutamyltransferase (GGT). We investigated whether vascular GGT influences the vasorelaxant effect of GSNO in isolated
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