F9507
Flumethasone
Synonym(s):
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-methylprednisolone, 6α-Fluorodexamethasone
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About This Item
Empirical Formula (Hill Notation):
C22H28F2O5
CAS Number:
Molecular Weight:
410.45
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
218-370-9
MDL number:
InChI key
WXURHACBFYSXBI-GQKYHHCASA-N
InChI
1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
SMILES string
[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
form
powder
color
white to off-white
solubility
acetic acid: 10 mg/mL
mode of action
cell membrane | interferes
storage temp.
2-8°C
Quality Level
Related Categories
Application
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.
Biochem/physiol Actions
Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding .
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Mei Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(1), 17-24 (2010-11-30)
A rapid, simple and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay was developed for the determination of dexamethasone (Dex) and dexamethasone sodium phosphate (Dex SP) in plasma and human cochlear perilymph. After proteins were precipitated with a mixture of acetonitrile
Dariusz Bednarek et al.
Veterinary microbiology, 96(1), 53-67 (2003-10-01)
The aim of this paper was to compare the effect of flumethasone and meloxicam in combination with oxytetracycline on clinical and immunological parameters of calves suffering from enzootic bronchopneumonia. The study was performed on 30 Black-and-White Lowland Breed calves with
Catherine A Loynes et al.
Journal of leukocyte biology, 87(2), 203-212 (2009-10-24)
Zebrafish are a unique model for pharmacological manipulation of physiological processes such as inflammation; they are small and permeable to many small molecular compounds, and being transparent, they permit the visualization and quantitation of the inflammatory response by observation of
K Sternbauer et al.
Zentralblatt fur Veterinarmedizin. Reihe A, 45(6-7), 441-443 (1998-10-30)
The impact of one single therapeutic dose of flumethasone (0.5 mg/100 kg b.w.) on insulin sensitivity was studied in calves. Hyperinsulinemic, euglycemic clamp tests were performed before and after flumethasone treatment. At 24 h after treatment, insulin-dependent glucose utilization was
Olivia Van Den Hauwe et al.
Journal of agricultural and food chemistry, 51(1), 326-330 (2002-12-28)
A field study was performed to assess the drug residue level in edible tissues after a therapeutic application of the synthetic glucocorticoids dexamethasone and flumethasone. Three diseased calves were injected intramuscularly with a commercial batch of dexamethasone esters and slaughtered
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