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F8257

Sigma-Aldrich

Flunarizine dihydrochloride

≥98% (TLC)

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Synonym(s):
1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
Empirical Formula (Hill Notation):
C26H26F2N2 · 2HCl
CAS Number:
30484-77-6
Molecular Weight:
477.42
Beilstein:
4284243
EC Number:
250-216-6
MDL number:
MFCD00058198
UNSPSC Code:
12352200
PubChem Substance ID:
24277835
NACRES:
NA.77

Quality Level

200

Assay

≥98% (TLC)

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4

InChI

1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;

InChI key

RXKMOPXNWTYEHI-RDRKJGRWSA-N

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General description

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Application

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Leybaert L, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
The effect of flunarizine on penicillin model epilepsy in rats
BAGIRICI F, et al.
Journal of Experimental and Clinical Medicine, 16(4) (1999)
Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
Overweg J, et al.
Epilepsia, 25(2), 217-222 (1984)
Li Li et al.
Circulation. Arrhythmia and electrophysiology, 6(6), 1192-1199 (2013-11-19)
Previous studies showed that endocardial activation during long-duration ventricular fibrillation (VF) exhibits organized activity. We identified and quantified the different types of organized activity. Two 64-electrode basket catheters were inserted, respectively, into the left ventricle and right ventricle of dogs
Hunmin Kim et al.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 17(1), 45-49 (2012-11-01)
The purpose of this study was to compare the efficacy and tolerability of topiramate and flunarizine for the prophylaxis of pediatric migraines. A retrospective medical-record review of patients who underwent prophylaxis after receiving a diagnosis of migraine with aura and
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