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About This Item
Empirical Formula (Hill Notation):
C13H10Cl2N2O4S
CAS Number:
Molecular Weight:
361.20
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: 20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cc(ccc1NS(=O)(=O)c2cc(Cl)ccc2Cl)[N+]([O-])=O
InChI
1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChI key
AXNUEXXEQGQWPA-UHFFFAOYSA-N
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
FH535 is a reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling antagonist. FH535 is unique in its ability to inhibit the Wnt/β-catenin pathway. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.
WGK
WGK 3
Certificates of Analysis (COA)
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Anupama Karnam et al.
Communications biology, 3(1), 96-96 (2020-03-07)
Therapeutic normal IgG intravenous immunoglobulin (IVIG) is a well-established first-line immunotherapy for many autoimmune and inflammatory diseases. Though several mechanisms have been proposed for the anti-inflammatory actions of IVIG, associated signaling pathways are not well studied. As β-catenin, the central
Fu-Lai Zhou et al.
Acta pharmacologica Sinica, 40(9), 1245-1255 (2019-05-30)
Chemical genomics has been applied extensively to evaluate small molecules that modulate biological processes in Saccharomyces cerevisiae. Here, we use yeast as a surrogate system for studying compounds that are active against metazoan targets. Large-scale chemical-genetic profiling of thousands of
FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases
Gustafson C T, et al.
Frontiers in Pharmacology, 8, 285-285 (2017)
FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt beta-catenin Signaling Pathway
Chen Y, et al.
Journal of Cancer, 8(16), 3142-3142 (2017)
Chiharu Kimura-Yoshida et al.
Nature communications, 9(1), 4059-4059 (2018-10-05)
Epithelial cell shape change is a pivotal driving force for morphogenesis of complex three-dimensional architecture. However, molecular mechanisms triggering shape changes of epithelial cells in the course of growth and differentiation have not been entirely elucidated. Grhl3 plays a crucial
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