F5554
Formalin, 10%, Neutral Buffered, Wintergreen Scented
histological fixative, pH 6.9-7.1
Synonym(s):
Formaldehyde, Methanal
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About This Item
UNSPSC Code:
12171500
NACRES:
NA.47
Quality Level
shelf life
Expiry date on the label.
color
colorless
pH
6.90-7.10
application(s)
hematology
histology
storage temp.
room temp
Related Categories
General description
10% Neutral buffered formalin (NBF) is the most commonly used fixative for light microscopy. 10% NBF is well suited for large throughput laboratories and requires a relatively short period of fixation, but can also be used for the long-term storage of tissue. Formalin fixation is thought to form between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship.
Application
Formalin, 10%, Neutral Buffered, Wintergreen Scented has been used as a fixative in transformation and tumorigenicity assay and in immunohistostaining.
Intended for use as a general purpose histological fixative. Wintergreen oil has been added to the standard formulation to provide a wintergreen scent.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Effects of formalin fixation on tissue optical
M F G Wood
Physics in Medicine and Biology, 56, V115-V115 (2011)
Kelly B Engel et al.
Archives of pathology & laboratory medicine, 135(5), 537-543 (2011-04-30)
While formalin fixation and paraffin embedding has become a universal mechanism of tissue preservation and a gold standard for immunohistochemistry, fixation and processing variables that may confound assay effectiveness have received little attention from the scientific community. To identify discrete
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis
Dolado I, et al.
Cancer Cell, 11(2), 191-205 (2007)
Neither epithelial nor mesenchymal circulating tumor cells isolated from breast cancer patients are tumorigenic in NOD-scid Il2rg null mice
Donnenberg VS, et al.
NPJ breast cancer, 2, 16004-16004 (2016)
Toward deciphering proteomes of formalin-fixed paraffin-embedded (FFPE) tissues
Magdeldin, et al.
Proteomics, 12(7), 1045-1058 (2012)
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