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F5421

Sigma-Aldrich

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FGFR-1

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About This Item

MDL number:
MFCD00675556
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 110-120 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using trypsin-digested human and animal tissue sections
immunoprecipitation (IP): suitable
western blot: 1:400 using an extract of FGFR-1 transfected cells

UniProt accession no.

P11362

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FGFR1(2260)

Related Categories

General description

Fibroblast growth factor receptor 1 (FGFR-1) belongs to the family of FGFRs. At the mRNA level, FGFR-1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates.

Specificity

Anti-FGFR-1 antibody is specific for human FGFR-1 and does not react with human FGFR-2 and FGFR-3. The immunizing peptide specifically inhibits the staining of anti-FGFR-1 antibody.
Staining of the product is specifically inhibited with the FGFR-1 immunizing peptide. No reaction with human FGFR-2 and FGFR-3 is detected.
No reaction with FGFR-2 (Bek) and FGFR-3 is detected.

Immunogen

Synthetic peptide corresponding to amino acid residues 360-373 of the extracellular region of human FGFR-1 conjugated to KLH with glutaraldehyde, and with a C-terminally added lysine.

Application

Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunofluorocytochemistry
  • immunohistochemistry
  • immunoblotting

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

含少量动物源组分生物产品
常规特殊物品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
Sleeman IJ, et al.
Neuropharmacology, 63 (2012)
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
Peters KG, et al.
Development, 114 (1992)
Wei Zheng et al.
Developmental neuroscience, 26(2-4), 181-196 (2005-02-16)
Cells within the subventricular zone (SVZ) express basic Fgf (Fgf2) and Fgf receptor proteins. We show that the absence of Fgf2 gene products reduces by 50% the dividing progenitor population of the anterior SVZ (SVZa) without changing their cell cycle
Frank W King et al.
Stem cells and development, 18(10), 1441-1450 (2009-03-04)
Directed differentiation of human embryonic stem cells (hESCs) has generated much interest in the field of regenerative medicine. While subpopulations of hESCs within pluripotent cultures have been identified based on expression of specific surface antigens, their significance and fates are
A W Jonczyk et al.
Journal of dairy science, 102(11), 10573-10586 (2019-09-16)
Prostaglandin (PG) F2α and its analogs (aPGF2α) are used to induce regression of the corpus luteum (CL); their administration during the middle stage of the estrous cycle causes luteolysis in cattle. However, the bovine CL is resistant to the luteolytic
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