F3520
Anti-von Willebrand Factor antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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Synonym(s):
Von Willebrand Factor Antibody, Von Willebrand Factor Antibody - Anti-von Willebrand Factor antibody produced in rabbit, Anti-Factor VIII-Related Antigen
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human tissue (Indirect Immunoperoxidase Labeling)
indirect immunofluorescence: 1:200 using formalin-fixed, paraffin-embedded sections of human tissue
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VWF(7450)
Related Categories
General description
Anti-von Willebrand Factor is produced in rabbit using purified von Willebrand factor (factor VIII R:Ag) as the immunogen.
Human von Willebrand factor (factor VIII R:Ag) is a 270 kDa multimeric plasma gylcoprotein. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. The factor is synthesized by endothelial cells and is also present in platelets and megakaryocytes.
Specificity
The antibody specifically reacts with the cytoplasm of human endothelial cells from normal and neoplastic blood and from lymphatic vessels. It also reacts with human endocardium, platelets and megakaryocytes. It may be used for immunohistological studies of the vascular structures in frozen tissue preparations and enzymatically pre-digested, formalin, methacarn, Bouin′s or ethanol-fixed and paraffin-embedded tissue sections.
Immunogen
von Willebrand Factor (Factor VIII-related antigen) from human plasma.
Application
Anti-von Willebrand Factor antibody produced in rabbit has been used for:
- western blot analysis and immunostaining
- immunocytochemistry
- immunohistochemistry
- indirect immunofluorescence
Biochem/physiol Actions
It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Preparation Note
Whole antiserum is purified to provide an IgG fraction of antiserum.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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