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Key Documents

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F3388

Sigma-Aldrich

Ferric citrate

BioReagent, suitable for cell culture

Synonym(s):

Iron(III) citrate, Iron(III) citrate hydrate

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About This Item

Empirical Formula (Hill Notation):
C6H5FeO7
CAS Number:
3522-50-7
Molecular Weight:
244.94
EC Number:
222-536-6
MDL number:
MFCD00013098
UNSPSC Code:
12352205
PubChem Substance ID:
24894843
NACRES:
NA.75
Pricing and availability is not currently available.

biological source

synthetic (organic)

Quality Level

300

product line

BioReagent

technique(s)

cell culture | mammalian: suitable

solubility

hot water: 0.01 g/mL, clear, orange-yellow

shipped in

ambient

storage temp.

room temp

SMILES string

OC12CC(=O)O[Fe](OC(=O)C1)OC2=O

InChI

1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3

InChI key

NPFOYSMITVOQOS-UHFFFAOYSA-K

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Application

Ferric citrate provides a source of iron used in cell culture applications. It provides iron in a less toxic form than free iron salts. Ferric citrate has been used as medium supplement in human osteosarcoma cell (U2OS) culture,[1] human embryonic kidney (HEK293) cells[2] and adult primary cardiomyocytes.[3]

Biochem/physiol Actions

Ferric citrate is used as a component of protein-free medium. It is used as a substitute for transferrin in mouse hybridomas culture. Ferric citrate enhances IgM production.[4] It indirectly stimulates the mitogen-activated protein kinase (MAPK) by favoring high amphiregulin oncoprotein levels in colon cancer.[5]  Ferric citrate is effective in binding to phosphate in patients with dialysis-dependent chronic kidney disease.[6]

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000390503
    0000385395
    0000373685
    0000374496
    0000367501

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    Development of a protein-free medium with iron salts replacing transferrin for a human-human hybridoma
    Nagira K, et al.
    Bioscience, Biotechnology, and Biochemistry, 59(4), 743-745 (1995)
    Nonantibiotic effects of fluoroquinolones in mammalian cells
    Badal S, et al.
    The Journal of Biological Chemistry, 290(36), 22287-22297 (2015)
    Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells
    Scheers NM, et al.
    Oncotarget, 9(24), 17066-17066 (2018)
    An essential cell-autonomous role for hepcidin in cardiac iron homeostasis
    Lakhal-Littleton S, et al.
    eLife, 5, e19804-e19804 (2016)
    Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease
    Chertow GM, et al.
    PLoS ONE, 12(11), e0188712-e0188712 (2017)
    View All Related Papers

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