F3377
N-Formyl-L-methionine
≥90% (TLC)
Synonym(s):
fMet
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About This Item
Empirical Formula (Hill Notation):
C6H11NO3S
CAS Number:
Molecular Weight:
177.22
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
product name
N-Formyl-L-methionine, ≥90% (TLC)
Quality Level
Assay
≥90% (TLC)
form
powder
color
white
storage temp.
−20°C
SMILES string
CSCC[C@H](NC=O)C(O)=O
InChI
1S/C6H11NO3S/c1-11-3-2-5(6(9)10)7-4-8/h4-5H,2-3H2,1H3,(H,7,8)(H,9,10)/t5-/m0/s1
InChI key
PYUSHNKNPOHWEZ-YFKPBYRVSA-N
Related Categories
Application
N-Formyl-L-methionine (fMet) is used to identify, differentiate and characterize amino acid N-deformylase(s), N-carbamoylase(s) and N-aminoacylase(s).
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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T Martin Schmeing et al.
Nature structural biology, 9(3), 225-230 (2002-02-06)
The large ribosomal subunit catalyzes peptide bond formation during protein synthesis. Its peptidyl transferase activity has often been studied using a 'fragment assay' that depends on high concentrations of methanol or ethanol. Here we describe a version of this assay
Rouven Bingel-Erlenmeyer et al.
Nature, 452(7183), 108-111 (2008-02-22)
Messenger-RNA-directed protein synthesis is accomplished by the ribosome. In eubacteria, this complex process is initiated by a specialized transfer RNA charged with formylmethionine (tRNA(fMet)). The amino-terminal formylated methionine of all bacterial nascent polypeptides blocks the reactive amino group to prevent
Tetsuo Ohmachi et al.
Applied microbiology and biotechnology, 65(6), 686-693 (2004-08-10)
N-carbamoyl-L-cysteine amidohydrolase (NCC amidohydrolase) was purified and characterized from the crude extract of Escherichia coli in which the gene for NCC amidohydrolase of Pseudomonas sp. strain ON-4a was expressed. The enzyme was purified 58-fold to homogeneity with a yield of
M Guenneugues et al.
The EMBO journal, 19(19), 5233-5240 (2000-10-03)
The interaction between fMet-tRNA(f)(Met) and Bacillus stearothermophilus translation initiation factor IF2 has been characterized. We demonstrate that essentially all thermodynamic determinants governing the stability and the specificity of this interaction are localized within the acceptor hexanucleotide fMet-3'ACCAAC of the initiator
J Tomsic et al.
The EMBO journal, 19(9), 2127-2136 (2000-05-03)
Binding of the 50S ribosomal subunit to the 30S initiation complex and the subsequent transition from the initiation to the elongation phase up to the synthesis of the first peptide bond represent crucial steps in the translation pathway. The reactions
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