F2177
Follistatin 288 from mouse
>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Synonym(s):
FS-288
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About This Item
biological source
mouse
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
Assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
0.04-0.4 mg per mL
mol wt
calculated mol wt ~31 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Fst(14313)
General description
FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta.
Biochem/physiol Actions
FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells.
High affinity activin-binding protein that can act as an activin antagonist.
Physical form
Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Rita Linko et al.
BMC infectious diseases, 14, 253-253 (2014-06-03)
Activin A and its binding protein follistatin (FS) are increased in inflammatory disorders and sepsis. Overexpression of activin A in the lung causes similar histopathological changes as acute respiratory distress syndrome (ARDS). ARDS and severe respiratory failure are complications of
Silvia Näf et al.
PloS one, 9(4), e92175-e92175 (2014-04-26)
The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth. To analyze circulating activin A, follistatin and follistatin-like-3 (FSTL3) levels and their relationship with glucose metabolism in pregnant women
S Dasgupta et al.
Journal of postgraduate medicine, 58(3), 190-193 (2012-10-02)
Out of a panel of 37 candidate genes tested for linkage with polycystic ovary syndrome (PCOS), the strongest evidence of linkage was reported in the follistatin (FST) gene region. Subsequently, a couple of studies outside India investigated the FST gene
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