F134
S(+)-α-Fluoromethylhistidine hydrochloride
solid
Synonym(s):
MK-453, S(+)-α-FMH
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About This Item
Empirical Formula (Hill Notation):
C7H10FN3O2 · HCl
Molecular Weight:
223.63
MDL number:
UNSPSC Code:
12352200
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form
solid
color
off-white
solubility
H2O: 18 mg/mL
DMSO: 6.3 mg/mL
SMILES string
Cl.N[C@@](CF)(Cc1c[nH]cn1)C(O)=O
Biochem/physiol Actions
Histidine decarboxylase inhibitor.
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G D Prell et al.
Journal of neurochemistry, 66(5), 2153-2159 (1996-05-01)
In mammalian brain, histamine is known to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH), then tele-methylimidazoleacetic acid (t-MIAA). We previously showed that imidazoleacetic acid (IAA), a GABA agonist, and histamine's metabolite in the periphery, is present in
K Sugimoto et al.
Journal of neurochemistry, 65(2), 791-797 (1995-08-01)
The mast cell-deficient [Ws/Ws (White spotting in the skin)] rat was investigated with regard to the origin of histamine in the brain. No mast cells were detected in the pia mater and the perivascular region of the thalamus of Ws/Ws
Long-term depletion of brain histamine induced by α-fluoromethylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels.
Sakai, et al.
Behavioural Brain Research, 14, 83-88 (1995)
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