Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

F133

Sigma-Aldrich

Norfluoxetine hydrochloride

≥97%, solid

Synonym(s):

(±)-γ-(4-Trifluoromethylphenoxy)benzenepropanamine hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H16F3NO · HCl
CAS Number:
57226-68-3
Molecular Weight:
331.76
MDL number:
MFCD01321043
UNSPSC Code:
12352200
PubChem Substance ID:
24894760
NACRES:
NA.77

Quality Level

100

Assay

≥97%

form

solid

color

yellow

solubility

H2O: >4 mg/mL
DMSO: >5 mg/mL

SMILES string

Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H

InChI key

GMTWWEPBGGXBTO-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Biochem/physiol Actions

Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.
Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

Caution

Hygroscopic, photosensitive

Legal Information

Sold under license from Eli Lilly and Company.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
101M4621V
0000032185
0000025547
038K4611
086K2040

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

S Caccia
Clinical pharmacokinetics, 34(4), 281-302 (1998-05-08)
Several chemically unrelated agents has been developed and introduced in the past decade, to supplement the earlier antidepressants. These include inhibitors of the reuptake of serotonin [the selective serotonin reuptake inhibitors (SSRI)] or noradrenaline (reboxetine) or both (milnacipran and venlafaxine)
Timothy W Chow et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(5-6), 349-358 (2011-01-19)
A liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was developed and validated for the quantitation of (R)-, (S)-fluoxetine, and (R)-, (S)-norfluoxetine in ovine plasma. The analytes were extracted from ovine plasma at a basic pH using a single-step liquid-liquid extraction with
Fluoxetine and its active metabolite norfluoxetine disrupt estrogen synthesis in a co-culture model of the feto-placental unit
Thibeault A A H, et al.
Molecular and cellular endocrinology, 442, 32-39 (2017)
Dorothy Sit et al.
Journal of clinical psychopharmacology, 30(4), 381-386 (2010-07-16)
To add to the limited data on the clinical pharmacology of antidepressants during pregnancy, we examined the dose-corrected chiral and racemic levels (level/dose) of fluoxetine (FLX) and norfluoxetine (NorFLX) during pregnancy and early postpartum. The authors evaluated 17 pregnant women
E K Sawyer et al.
Pharmacology, 88(1-2), 44-49 (2011-07-16)
Fluoxetine (Prozac) is a selective serotonin reuptake inhibitor currently used to treat depression and mood disorders. It has been widely studied clinically and preclinically, yet there is limited knowledge of its pharmacokinetics in nonhuman primates. The present study characterized the
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service