EPI009
Histone Deacetylase (HDAC) Inhibitor Set II
Set includes 7 inhibitors
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UNSPSC Code:
12352200
NACRES:
NA.41
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shipped in
wet ice
storage temp.
−20°C
General description
A convenient set of seven individual HDAC (Histone Deacetylase) inhibitors.
Molecular Formula: C15H15N3O2
Molecular Weight: 269.3
Molecular Formula: C21H23N3O2
Molecular Weight: 349.43
Molecular Formula: C14H20N2O3
Molecular Weight: 264.3
Molecular Formula: C8H16N2O4
Molecular Weight: 204.22
Molecular Formula: C18H18N2O4
Molecular Weight: 326.35
Molecular Formula: C17H22N2O3
Molecular Weight: 302.4
Molecular Formula: C41H43N3O7S
Molecular Weight: 721.86
- CI-994
Molecular Formula: C15H15N3O2
Molecular Weight: 269.3
- Panobinostat (LBH589)
Molecular Formula: C21H23N3O2
Molecular Weight: 349.43
- SAHA
Molecular Formula: C14H20N2O3
Molecular Weight: 264.3
- SBHA
Molecular Formula: C8H16N2O4
Molecular Weight: 204.22
- Scriptaid
Molecular Formula: C18H18N2O4
Molecular Weight: 326.35
- Trichostatin A
Molecular Formula: C17H22N2O3
Molecular Weight: 302.4
- Tubacin
Molecular Formula: C41H43N3O7S
Molecular Weight: 721.86
Biochem/physiol Actions
- CI-994 - Cell-permeable. A histone deacetylase (HDAC) inhibitor: Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8, respectively. Displays significant antitumor activity in vitro and in vivo against a broad spectrum of murine and human tumor models.
- Panobinostat (LBH589) - Highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8 nM.
- SAHA - Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Induces cell growth arrest at both G1 and G2 phases. Induces apoptosis.
- SBHA - Competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or apoptosis. SBHA also enhances cytotoxicity induced by Oxaliplatin in the colorectal cancer cell lines.
- Scriptaid - A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-ß/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 μg/ml (6-8 μM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells.
- Trichostatin A - Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.
- Tubacin - Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC50 = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of α-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated α-tubulin deacetylation in mammalian cells.
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Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Muta. 2 - Repr. 1A - Skin Irrit. 2 - STOT RE 2 Inhalation
WGK
WGK 3
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Regulatory Information
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