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EMU090851

MISSION® esiRNA

targeting mouse Pim1

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About This Item

NACRES:
NA.51
UNSPSC Code:
41105324

Key Documents

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Product Name

MISSION® esiRNA, targeting mouse Pim1

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

CGACATCAAGGACGAGAACATCTTAATCGACCTGAGCCGCGGCGAAATCAAACTCATCGACTTCGGGTCGGGGGCGCTGCTCAAGGACACAGTCTACACGGACTTTGATGGGACCCGAGTGTACAGTCCTCCAGAGTGGATTCGCTACCATCGCTACCACGGCAGGTCGGCAGCTGTCTGGTCCCTTGGGATCCTGCTCTATGACATGGTCTGCGGAGATATTCCGTTTGAGCACGATGAAGAGATCATCAAGGGCCAAGTGTTCTTCAGGCAAACTGTCTCTTCAGAGTGTCAGCACCTTATTAAATGGTGCCTGTCCCTGAGACCATCAGATCGGCCCTCCTTTGAAGAAATCCGGAACCATCCATGGATGCAGGGTGACCTCCTGCCCCAGGCAGCTTCTGAGATCCATCTGCACAGTCTGTCACCGGGGTCCAGCAAGTAGCAGCCTTTCTGCTGCTGTCTGTCAGACCCTCCAGGGAGGGAGAGCTTGTCTTCTGGCCTCCCAACAGGACCCTGCGTGACGATGCAGGGACAGCAATGACAACTCATTCCAGACTCCAGGTCC

Ensembl | mouse accession no.

ENSMUSG00000024014

NCBI accession no.

NM_008842

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Gene Information

mouse ... PIM1(18712), Pim1(18712)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Meng Zhang et al.
Cancer science, 109(5), 1468-1479 (2018-03-09)
Cancer cells metabolize glucose mainly by glycolysis and are well adapted to metabolic stress. Pim1 is an oncogene that promotes colorectal cancer (CRC) growth and metastasis, and its expression is positively correlated with CRC progression. However, the mechanism underlying Pim1
Shabana Din et al.
Circulation research, 115(3), 376-387 (2014-06-12)
The senescent cardiac phenotype is accompanied by changes in mitochondrial function and biogenesis causing impairment in energy provision. The relationship between myocardial senescence and Pim kinases deserves attention because Pim-1 kinase is cardioprotective, in part, by preservation of mitochondrial integrity.

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