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Key Documents

Safety Information

EHU148901

Sigma-Aldrich

MISSION® esiRNA

targeting human CYP3A4

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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

CN¥1,000.26

List priceCN¥1,445.76Save 31%

Available to ship onApril 09, 2025Details

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250 G
CN¥1,000.26
1 KG
CN¥4,616.55

About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

CN¥1,000.26

List priceCN¥1,445.76Save 31%

Available to ship onApril 09, 2025Details

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAATAAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAATGAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTTGAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTTCACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAGAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAACTGCATT

Ensembl | human accession no.

ENSG00000160868

NCBI accession no.

NM_017460

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CYP3A4(1576) , CYP3A4(1576)

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106018

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Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

assay

≥99.9% (GC)

assay

≥99.8% (GC)

assay

≥99.8% (GC)

assay

-

technique(s)

HPLC: suitable

technique(s)

HPLC: suitable

technique(s)

-

technique(s)

-

form

liquid

form

liquid

form

liquid

form

-

vapor pressure

128 hPa ( 20 °C), 97.68 mmHg ( 20 °C), 410 mmHg ( 50 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

128 hPa ( 20 °C), 410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

vapor pressure

410 mmHg ( 50 °C), 97.68 mmHg ( 20 °C)

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Yuji Ishida et al.
    PloS one, 15(9), e0239540-e0239540 (2020-09-24)
    Aflatoxin B1 (AFB1), a mycotoxin, is acutely hepatotoxic to many animals including humans. However, there are marked interspecies differences in sensitivity to AFB1-induced toxicity depending on bioactivation by cytochrome P450s (CYPs). In the present study, we examined the applicability of
    Liliana Mancio-Silva et al.
    Cell metabolism, 29(3), 727-735 (2019-03-07)
    The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In

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