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If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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Key Documents

Safety Information

EHU119391

Sigma-Aldrich

MISSION® esiRNA

targeting human GPX4

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GCACATGGTTAACCTGGACAAGTACCGGGGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTACACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTCCCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCCGCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCCCACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCCATCAAGTGGAACTTCACCAAGTTCCTCATCGACAAGAACGGCTGCGTGGTGAAGCGCTACGGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCTGCCCC

Ensembl | human accession no.

ENSG00000167468

NCBI accession no.

NM_002085

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... GPX4(2879) , GPX4(2879)

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F0504M1891C4874
Hyaluronic Acid Binding Protein bovine lyophilized powder

H0161

Hyaluronic Acid Binding Protein bovine

Folate binding protein from bovine milk lyophilized powder

F0504

Folate binding protein from bovine milk

Myelin Basic Protein bovine ≥90% (SDS-PAGE), lyophilized powder, suitable for activity assay

M1891

Myelin Basic Protein bovine

Calmodulin bovine recombinant, expressed in E. coli, lyophilized powder, ≥98% (SDS-PAGE)

C4874

Calmodulin bovine

biological source

bovine

biological source

bovine milk

biological source

bovine

biological source

bovine

technique(s)

immunofluorescence: suitable

technique(s)

ligand binding assay: suitable, surface plasmon resonance (SPR): suitable

technique(s)

activity assay: suitable

technique(s)

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

P81282

UniProt accession no.

-

UniProt accession no.

P02687

UniProt accession no.

P62157

Gene Information

cow ... VCAN(282662)

Gene Information

-

Gene Information

cow ... MBP(618684)

Gene Information

bovine ... CALM(100297344)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Xuefei Zhang et al.
    Journal of cellular physiology, 235(4), 3425-3437 (2019-09-27)
    Glutathione peroxidase 4 (GPX4) has been confirmed to inhibit ferroptosis in cancer cells, however, whether GPX4 serves as an oncogene is not clear. In this study, the expression of GPX4 and its influence to survival of patients with cancer were
    Zongqi Wang et al.
    Cancer letters, 428, 21-33 (2018-04-28)
    Ferroptosis is a form of programmed cell death decided by iron-dependent lipid peroxidation, but its role in glioma cell death remains unclear. In this study, we found Pseudolaric acid B (PAB) inhibited the viabilities of glioma cells in vitro and in vivo
    Lisa Mayr et al.
    Nature communications, 11(1), 1775-1775 (2020-04-15)
    The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by enrichment with the ω-6 polyunsaturated fatty acid (PUFA) arachidonic

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