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EHU062241

Sigma-Aldrich

MISSION® esiRNA

targeting human ADPRHL2

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

CATGGAGGAGCGTCCATACTCCAGCCGCCTGAAGAAGATTGGAGAGCTTCTAGACCAGGCATCGGTGACCAGGGAGGAAGTGGTGTCTGAGCTAGGGAATGGCATTGCTGCCTTTGAGTCGGTACCCACCGCCATCTACTGCTTCCTACGCTGCATGGAGCCAGACCCTGAGATCCCTTCTGCCTTCAATAGCCTCCAAAGGACTCTCATTTATTCCATCTCACTTGGTGGGGACACAGACACCATTGCCACCATGGCTGGGGCCATTGCTGGTGCCTACTATGGGATGGATCAGGTGCCAGAGAGCTGGCAGCAAAGCTGTGAAGGCTACGAGGAGACAGACATCCTGGCCCAAAGCCTGCACCGTGTCTTCCAGAAGAGTTGATGAGGGCTACAGCTGTTGGGGCTCTGCCAGGTCCCCTGGGACCAACTACAGCTCCAATCAGAAACCCTGCGCTTCCTTGAGTGTGGCTTC

Ensembl | human accession no.

ENSG00000116863

NCBI accession no.

NM_017825

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... ADPRHL2(54936) , ADPRHL2(54936)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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Hana Hanzlikova et al.
Nature communications, 11(1), 3391-3391 (2020-07-09)
Neurodegeneration is a common hallmark of individuals with hereditary defects in DNA single-strand break repair; a process regulated by poly(ADP-ribose) metabolism. Recently, mutations in the ARH3 (ADPRHL2) hydrolase that removes ADP-ribose from proteins have been associated with neurodegenerative disease. Here

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