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EHU044061

Sigma-Aldrich

MISSION® esiRNA

targeting human GPR55

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UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TTCTTCCTGCAGTTCCTGGTGAGAAACAGCTTTATCGTAGAGTGCAGAGCCAAGCAGAGCATCAGCTTCTTCTTGCAATTGTCCATGTGTTTCTCCAACGTCAACTGCTGCCTGGATGTTTTCTGCTACTACTTTGTCATCAAAGAATTCCGCATGAACATCAGGGCCCACCGGCCTTCCAGGGTCCAGCTGGTCCTGCAGGACACCACGATCTCCCGGGGCTAACGGAAGGACATCCTGTTCAGGGGAAGAAAGCCCTGGCCCTGAATTCTGGTAACGGATATCGCGTTCCAGGGTTTTGATGTGGTGGGATGATCCGCACCATCTTCACTGATGTGCTTCCCTTTGATGCCCATTGAGTGCCAGCTTTGCTCATTATACCCCAAAGACCTTTTTTCCACTGCCCAGACAGCTTATACCACCCAGTGTTCAGGGATCTCTGAAGAACCCACAGACCAGGTG

Ensembl | human accession no.

ENSG00000135898

NCBI accession no.

NM_005683

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... GPR55(9290) , GPR55(9290)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Christopher Lipina et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1299-1312 (2018-08-28)
Emerging evidence indicates that G-protein coupled receptor 55 (GPR55), a nonclassic receptor of the endocannabinoid system that is activated by L-α-lysophosphatidylinositol and various cannabinoid ligands, may regulate endocrine function and energy metabolism. We examined how GPR55 deficiency and modulation affects
Sara Carpi et al.
Anti-cancer drugs, 26(7), 754-762 (2015-05-15)
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma
Nicole A Hofmann et al.
British journal of pharmacology, 172(16), 4107-4118 (2015-05-20)
Highly vascularized ovarian carcinoma secretes the putative endocannabinoid and GPR55 agonist, L-α-lysophosphatidylinositol (LPI), into the circulation. We aimed to assess the involvement of this agonist and its receptor in ovarian cancer angiogenesis. Secretion of LPI by three ovarian cancer cell

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